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EV and PV penetration impact on grid with conservative voltage regulation and reactive voltage compensation.
ISA Trans
January 2025
Tenaga Nasional Berhad - Distribution, Kuala Lumpur, Selangor, Malaysia. Electronic address:
As global interest grows in renewable energy sources, the impact of combined Electric Vehicle (EV) and PhotoVoltaic (PV) penetration on the power grid stability requires renewed attention, to incorporate new technologies to maintain the power quality under operational constraints. Energy-saving techniques such as Conservation Voltage Reduction (CVR) allow the power utilities to transmit voltage at a lower operation limit, increasing the generation margin to absorb the peak load demands. Increased reverse PV penetration results in grid overvoltage while EV charging absorbs the reactive power causing grid instability.
View Article and Find Full Text PDFPrediction of implant failure risk due to periprosthetic femoral fracture after primary elective total hip arthroplasty : a simplified and validated model based on 154,519 total hip arthroplasties from the Swedish Arthroplasty Register.
Bone Joint Res
January 2025
Department of Orthopaedics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg, Sweden.
Aims: While cementless fixation offers potential advantages over cemented fixation, such as a shorter operating time, concerns linger over its higher cost and increased risk of periprosthetic fractures. If the risk of fracture can be forecasted, it would aid the shared decision-making process related to cementless stems. Our study aimed to develop and validate predictive models of periprosthetic femoral fracture (PPFF) necessitating revision and reoperation after elective total hip arthroplasty (THA).
View Article and Find Full Text PDFCMTM4 promotes the motility of colon cancer cells under radiation and is associated with an unfavorable neoadjuvant chemoradiotherapy response and patient survival in rectal cancer.
Oncol Lett
March 2025
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P.R. China.
Neoadjuvant chemoradiotherapy (nCRT) is the standard treatment for locally advanced rectal cancer (LARC). Pathological complete regression is closely linked to disease outcomes. However, biomarkers predicting nCRT response and patient survival are lacking for LARC.
View Article and Find Full Text PDFGlioma-induced alterations in excitatory neurons are reversed by mTOR inhibition.
Neuron
January 2025
Department of Pathology and Cell Biology, Irving Cancer Research Center, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Neurological Surgery, Columbia University Irving Medical Center, New York, NY 10032, USA. Electronic address:
Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been implicated in glioma-induced neuronal hyperexcitability, but the molecular and functional consequences have not been identified. Here, we show three types of changes in tumor-associated neurons: (1) downregulation of transcripts encoding excitatory and inhibitory postsynaptic proteins and dendritic spine development and upregulation of cytoskeletal transcripts via neuron-specific profiling of ribosome-bound mRNA, (2) marked decreases in dendritic spine density via light and electron microscopy, and (3) progressive functional alterations leading to neuronal hyperexcitability via in vivo calcium imaging.
View Article and Find Full Text PDFHydrogel loaded with cerium-manganese nanoparticles and nerve growth factor enhances spinal cord injury repair by modulating immune microenvironment and promoting neuronal regeneration.
J Nanobiotechnology
January 2025
Department of Orthopedics, Huashan Hospital, Fudan University, No. 12, Middle Wulumuqi Road, Jing'an District, Shanghai, 200040, China.
Background: Spinal cord injury (SCI) treatment remains a formidable challenge, as current therapeutic approaches provide only marginal relief and fail to reverse the underlying tissue damage. This study aims to develop a novel composite material combining enzymatic nanoparticles and nerve growth factor (NGF) to modulate the immune microenvironment and enhance SCI repair.
Methods: CeMn nanoparticles (NP) and CeMn NP-polyethylene glycol (PEG) nanozymes were synthesized via sol-gel reaction and DSPE-mPEG modification.
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