AI Article Synopsis
- This study examines oxidative stress markers in hemodialysis patients, focusing on regional differences and the impact of vitamin E-coated membranes.
- Baseline measurements of LDL oxidizability were taken from patients at five facilities, followed by a crossover trial comparing vitamin E membranes to standard membranes over several months.
- Results revealed regional variations in LDL oxidizability, but no significant benefits from using vitamin E membranes in improving these oxidative stress markers.
Article Abstract
Background/aims: This study aimed at evaluating oxidative stress (OS) markers (i) in a cross-sectional study of hemodialysis (HD) patients to investigate potential regional effects of these markers and (ii) in a prospective crossover study to evaluate vitamin E-coated membrane (VE) effects.
Methods: At baseline, OS parameters including low-density lipoprotein (LDL) oxidizability were measured in HD patients from five dialysis facilities. Patients were then randomly assigned to two treatment groups: group I patients (n = 33) switching to VE, and group II patients (n = 29) still using reference polysulfone (PS) membrane. After 3 months, patients were switched from VE to PS and vice versa for 6 months. The same OS parameters were measured after each period.
Results: At baseline, the cross-sectional analysis of LDL oxidizability showed a regional effect. By contrast, the crossover study did not show beneficial effects of VE on this parameter.
Conclusion: Regional variations of LDL oxidizability in HD patients exist and may explain discrepancies in interventional therapy on OS.
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| http://dx.doi.org/10.1159/000128991 | DOI Listing |
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