The preparation and characterization of n-alkane/water emulsions using beta-cyclodextrin (beta-CD) were studied. The prepared n-alkane/water emulsions were of the oil-in-water (O/W) type, and the stability of emulsions was in the order of n-hexadecane > n-dodecane > n-octane. From observations using polarized light microscopy and powder X-ray diffraction measurement, it was suggested that the formation of a dense film at the oil-water interface and the three-dimensional structural network created by precipitated complexes in the continuous phase are associated with the stability of emulsion. Furthermore, it was clarified that O/W-type emulsions were formed because the contact angle (theta ow) which the precipitate makes with the interface was theta ow < 90 degrees in all compounds (oils) used in this study.
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http://dx.doi.org/10.1248/cpb.56.668 | DOI Listing |
Int J Biol Macromol
December 2024
College of Food Science and Technology, Henan University of Technology, Zhengzhou, China.
The objective of this study was to solve instability and low bioavailability of tea polyphenols (TPs), and to explore the application of gluten protein as microcapsule wall material. Modified gluten protein (MEG), β-cyclodextrin (β-CD), xanthan gum (XG) or acacia gum (GA) were used as composite wall materials to encapsulate TPs by double-emulsion technique, and the physicochemical and structural properties of the products were characterized. The results show that the composite wall material effectively encapsulated and enhanced the stability of TPs.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Jiaxing Institute of Future Food, Jiaxing 314050, Zhejiang Province, People's Republic of China; Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China. Electronic address:
Phloretin (PHT) is a natural functional compound with antioxidant properties. However, its poor water solubility and high sensitivity to extreme pH environments, oxygen, and high temperatures limit its absorption and stability. Therefore, in this study, amorphous octenyl succinic anhydride starch (AOS) was employed to enhance the stability of PHT-loaded emulsions, and characteristics of these emulsions were evaluated.
View Article and Find Full Text PDFADMET DMPK
August 2024
Department of Life Sciences and Biotechnology, University of Ferrara, Via Fossato di Mortara 19, 44121 Ferrara, Italy.
Background And Purpose: Aiming to achieve light sedation via intranasal administration, this study showed that propofol (PPF) did not permeate across the rabbit nasal mucosa ex vivo from its marketed emulsion for injection.
Experimental Approach: Dilution of the emulsion with methyl-β-cyclodextrin in saline solution increased propofol solubility in water and diffusion across the nasal epithelium.
Key Results And Conclusion: Despite these positive effects of the cyclodextrin, the amount of PPF permeated was minimal in 3 h, exceeding the formulation residence time in the nose.
CNS Drugs
January 2025
Department of Anesthesiology, Jefferson Surgical Center Endoscopy, Sidney Kimmel Medical College, Jefferson Health, 111 S 11th Street, #7132, Philadelphia, PA, 19107, USA.
GABA (γ-aminobutyric acid) receptors are constituents of many inhibitory synapses within the central nervous system. They are formed by 5 subunits out of 19 various subunits: α1-6, β1-3, γ1-3, δ, ε, θ, π, and ρ1-3. Two main subtypes of GABA receptors have been identified, namely GABAA and GABAB.
View Article and Find Full Text PDFFood Hydrocoll
February 2025
Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca 14853, NY, USA.
Inclusion complexes of β-cyclodextrin (β-CD) and tryptophan (Trp) were synthesized using an antisolvent approach, and fully characterized. Scanning electron microscope images proved the formation of the β-CD/Trp NPs and the powder X-ray diffraction pattern indicated the formation of a crystalline channel-like structure for the β-CD/Trp nanoparticles (NPs). The NPs of a β-CD/Trp inclusion complex were used as a natural stabilizer at the oil/water interface of a Pickering emulsion.
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