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Engineering a membrane-binding protein to trimerize and induce high membrane curvature.
Biophys J
July 2023
University of Southern Denmark, PHYLIFE: Physical Life Science, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Odense, Denmark. Electronic address:
The annexins are a family of Ca-dependent peripheral membrane proteins. Several annexins are implicated in plasma membrane repair and are overexpressed in cancer cells. Annexin A4 (ANXA4) and annexin A5 (ANXA5) form trimers that induce high curvature on a membrane surface, a phenomenon deemed to accelerate membrane repair.
View Article and Find Full Text PDFPhenothiazines alter plasma membrane properties and sensitize cancer cells to injury by inhibiting annexin-mediated repair.
J Biol Chem
August 2021
Membrane Integrity, Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Article Synopsis
- Repair of damaged plasma membranes in eukaryotic cells relies on annexin proteins binding to phospholipids, and cancer cells are particularly reliant on this repair process due to their heightened membrane stress.
- Altering the membrane's physical properties may hinder annexin's repair ability, potentially increasing the susceptibility of cancer cells to damage.
- Research shows that phenothiazine derivatives, like trifluoperazine, can weaken the membrane and reduce annexin binding, making cancer cells more vulnerable to various forms of injury, suggesting a new strategy for cancer treatment.
Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair.
Cells
April 2020
Membrane Integrity, Cell Death and Metabolism Unit, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, DK-2100 Copenhagen, Denmark.
The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair tools that depend on Ca- and phospholipid-binding annexin proteins.
View Article and Find Full Text PDFMYB30 transcription factor regulates oxidative and heat stress responses through ANNEXIN-mediated cytosolic calcium signaling in Arabidopsis.
New Phytol
October 2017
State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China.
Cytosolic calcium signaling is critical for regulating downstream responses in plants encountering unfavorable environmental conditions. In a genetic screen for Arabidopsis thaliana mutants defective in stress-induced cytosolic free Ca ([Ca ] ) elevations, we identified the R2R3-MYB transcription factor MYB30 as a regulator of [Ca ] in response to H O and heat stresses. Plants lacking MYB30 protein exhibited greater elevation of [Ca ] in response to oxidative and heat stimuli.
View Article and Find Full Text PDFPotato Annexin STANN1 Promotes Drought Tolerance and Mitigates Light Stress in Transgenic Solanum tuberosum L. Plants.
PLoS One
May 2016
Plant Pathogenesis Lab, Institute of Biochemistry and Biophysics Polish Academy of Science, Warsaw, Poland.
Annexins are a family of calcium- and membrane-binding proteins that are important for plant tolerance to adverse environmental conditions. Annexins function to counteract oxidative stress, maintain cell redox homeostasis, and enhance drought tolerance. In the present study, an endogenous annexin, STANN1, was overexpressed to determine whether crop yields could be improved in potato (Solanum tuberosum L.
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