AI Article Synopsis
- The human leukocyte antigen (HLA) alleles show high variability across different ethnic groups, leading to diverse peptide-binding capabilities.
- Many of these alleles can be grouped into a few HLA supertypes that bind similar peptides but have unique profiles.
- This study focuses on using structural data to clarify how the HLA-A2 supertypes function at a molecular level.
Article Abstract
The human leukocyte antigen (HLA) alleles are extremely polymorphic among ethnic population, and the peptide-binding specificity varies for different alleles in a combinatorial manner. However, it has been suggested that majority of alleles can be covered within few HLA supertypes, where different members of a supertype bind similar peptides, yet exhibiting distinct repertoires. Nonetheless, the structural basis for HLA supertype-like function is not clearly known. Here, we use structural data to explain the molecular basis for HLA-A2 supertypes.
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| http://dx.doi.org/10.1007/978-1-60327-118-9_10 | DOI Listing |
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