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Introduction: China implemented a dynamic zero-COVID strategy to curb viral transmission in response to the coronavirus disease 2019 (COVID-19) pandemic. This strategy was designed to inhibit mutation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for COVID-19. This study explores the dynamics of viral evolution under stringent non-pharmaceutical interventions (NPIs) through real-world observations.
View Article and Find Full Text PDFIdentification of Host-Protein Interaction Network of Canine Parvovirus Capsid Protein VP2 in F81 Cells.
Microorganisms
January 2025
Beijing Key Laboratory for Prevention and Control of Infectious Diseases in Livestock and Poultry, In-Stitute of Animal Husbandry and Veterinary Medicine, Beijing Academy of Agriculture and Forestry Sciences, Beijing 100097, China.
Canine Parvovirus (CPV) is a highly contagious virus that causes severe hemorrhagic enteritis and myocarditis, posing a major threat to the life and health of dogs. The molecular mechanism by which VP2, the major capsid protein of CPV, infects host cells and utilizes host cell proteins for self-replication remains poorly understood. In this study, 140 host proteins specifically binding to CPV VP2 protein were identified by immunoprecipitation combined with liquid chromatography-mass spectrometry (LC-MS/MS).
View Article and Find Full Text PDFInfluence of spp. and Infection on Growth Performance and Toltrazuril Residues in Chickens.
Animals (Basel)
January 2025
Department of Basic and Preclinical Sciences, Faculty of Biological and Veterinary Sciences, Nicolaus Copernicus University in Torun, 11 Gagarina Street, 87-100 Toruń, Poland.
Coccidiosis and necrotic enteritis are among the most common diseases affecting poultry, with economic impact due to reduced production and the costs of treatment and prevention. Eimeria invasion contributes to gut damage that promotes the growth of other harmful pathogens, such as . Coccidiostats, with toltrazuril as an example, are widely used to control these infections.
View Article and Find Full Text PDFCase report: Cancer-free survival after chemotherapy, targeted immunotherapy combination with proton therapy following space making technique in a patient with cholangiocarcinoma after choledochal cyst resection.
Front Immunol
January 2025
Department of Hepatobiliary-Pancreatic-Splenic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Choledochal cysts (CCs) are rare cystic dilations of the intrahepatic and/or extrahepatic bile ducts. Malignancies arising during follow-up after excision of CCs have been reported in both children and adults, with no typical time frame for malignancy development. We present a case of a patient diagnosed with CCs 36 years ago, who underwent resection and subsequently developed cancer.
View Article and Find Full Text PDFPrevalence and genetic characterization of viral gastroenteritis in hospitalized children aged <5 years in Yunnan Province, China, 2020-2022.
Front Pediatr
January 2025
Yunnan Provincial Key Laboratory of Public Health and Biosafety & Institute for AIDS/STD Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, Yunnan, China.
Article Synopsis
- The study focused on the prevalence of various viruses causing acute gastroenteritis (AGE) in children under five years old in Yunnan, China.
- Over 610 stool samples were analyzed, revealing that rotavirus (RVA) was present in nearly 29% of the cases, with G8P[8] emerging as the dominant genotype in 2022.
- Norovirus was detected in about 12% of the samples, with GII.4 being the most common strain, while other viruses like sapovirus and human adenovirus had lower positivity rates.
- The results indicated higher AGE incidence in male children, particularly among those aged 12-23 months, with infection rates peaking in the early months of the year, highlighting
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