Objective: The prevalence and correlates of overweight and the risk of overweight in minority children attending urban school-based health centers remains poorly characterized. The purpose of our study was to examine the prevalence and characteristics of overweight and at risk for overweight in low socioeconomic status minority children enrolled in East Harlem school-based health centers in New York City.
Design: A retrospective cross-sectional study during the period of September 2002 to August 2003.
Setting: Four Pediatric School-based Health Centers in East Harlem.
Participants: Children and adolescents, aged 5 to 18 years.
Main Outcome Measures: We examined presence of overweight or the risk of overweight based on body mass index (BMI) percentile and other clinical characteristics. Bivariate and multivariate analyses were performed to assess the relationship between demographics and clinical characteristics with overweight and the risk of overweight.
Results: Of the 491 children enrolled, 45.8% were either overweight or at risk for overweight, with the highest risk observed in Hispanic/Latino children. This latter relation remained significant after adjusting for age, sex, and birthweight status. In addition, high screening office blood pressure was related to overweight status and higher BMI percentile.
Conclusions: A large proportion of minorities, especially Hispanic/Latino children, attending school-based health centers in an urban community sample, are overweight or at risk for overweight. Elevated screening blood pressure was also a common co-morbidity. Further research should determine the predictors and correlates of overweight, and effective targeted school-based interventions should be tested in this high-risk population.
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Lipids Health Dis
January 2025
Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Background: Age-related macular degeneration (AMD) decrease vision and presents considerable challenges for both public health and clinical management strategies. Obesity is usually implicated with increased AMD, and body mass index (BMI) does not reflect body fat distribution. An array of studies has indicated a robust relationship between body fat distribution and obesity.
View Article and Find Full Text PDFBMC Pregnancy Childbirth
January 2025
Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Background: Inadequate and excessive gestational weight gain (GWG) defined by the Institute of Medicine (IOM) has been associated with preterm birth. However, studies demonstrate inconsistent associations.
Objectives: We examined the associations between categorical and continuous total GWG and moderate to late preterm birth (32-<37 weeks), and evaluated differences in these associations by pre-pregnancy BMI.
J Hepatol
January 2025
MASLD Research Center, Division of Gastroenterology and Hepatology, University of California at San Diego, La Jolla, CA, USA.
Background & Aims: A common genetic variant (rs738409) encoding isoleucine to methionine at position 148 in the PNPLA3 protein is a determinant of hepatic steatosis, inflammation, fibrosis, cirrhosis, and liver-related mortality. AZD2693 is a liver-targeted antisense oligonucleotide against PNPLA3 mRNA. We evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics in single ascending dose (SAD) and multiple ascending dose (MAD) studies.
View Article and Find Full Text PDFJACC Cardiovasc Imaging
January 2025
Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:
Background: Implementation of semaglutide weight loss therapy has been challenging due to drug supply and cost, underscoring a need to identify those who derive the greatest absolute benefit.
Objectives: Allocation of semaglutide was modeled according to coronary artery calcium (CAC) among individuals without diabetes or established atherosclerotic cardiovascular disease (CVD).
Methods: In this analysis, 3,129 participants in the MESA (Multi-Ethnic Study of Atherosclerosis) without diabetes or clinical CVD met body mass index criteria for semaglutide and underwent CAC scoring on noncontrast cardiac computed tomography.
Obes Rev
January 2025
Department of Kinesiology, Michigan State University, East Lansing, Michigan, USA.
The purpose of this study was to calculate the effects of recent eHealth interventions to promote physical activity in young, middle-aged, and late middle-aged adults with obesity or overweight. This meta-analysis followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. In the search, 3550 articles were identified, and 15 studies met all inclusion criteria.
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