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Synaptoneurolipidomics: lipidomics in the study of synaptic function.
Trends Biochem Sci
January 2025
Research Group Neuroplasticity, Leibniz Institute for Neurobiology, Magdeburg, Germany; Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg, Germany; German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany. Electronic address:
The brain is an exceptionally lipid-rich organ with a very complex lipid composition. Lipids are central in several neuronal processes, including membrane formation and fusion, myelin packing, and lipid-mediated signal transmission. Lipid diversity is associated with the evolution of higher cognitive abilities in primates, is affected by neuronal activity, and is instrumental for synaptic plasticity, illustrating that lipids are not static components of synaptic membranes.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany.
Background: Lewy body pathology (LBP) is common in autosomal dominant (ADAD) or sporadic Alzheimer disease (sAD). LBP seems to be the most frequent co-pathology in sAD and even in the relatively young ADAD population, where other co-pathologies are rare. Knowledge of neuropathological distribution patterns of LBP and associated survival and genetic characteristics in both AD variants is incomplete.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Clinique Interdisciplinaire de Mémoire, CHU de Québec-Université Laval, Quebec, QC, Canada.
Background: Patients with Primary Progressive Aphasias (PPAs) almost systematically inquire about the longitudinal evolution of their disease in clinics but very little research exists on the issue.
Method: We studied 82 PPA patients from the Research Chair on PPA - Fondation de la Famille Lemaire Cohort over a 10-year span (42 logopenic, 21 non-fluent/agrammatic and 19 semantic PPAs) and collected data from 5 domains (language, cognition, motor, psychiatric, functional) at 5 time points from onset to death. Logistical regression analyses and repeated measures ANOVAs were conducted to delineate the longitudinal profile of each variant PPA.
Modern biology of extrachromosomal DNA: A decade-long voyage of discovery.
Cell Res
January 2025
Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Genomic instability is a hallmark of cancer and is a major driving force of tumorigenesis. A key manifestation of genomic instability is the formation of extrachromosomal DNAs (ecDNAs) - acentric, circular DNA molecules ranging from 50 kb to 5 Mb in size, distinct from chromosomes. Ontological studies have revealed that ecDNA serves as a carrier of oncogenes, immunoregulatory genes, and enhancers, capable of driving elevated transcription of its cargo genes and cancer heterogeneity, leading to rapid tumor evolution and therapy resistance.
View Article and Find Full Text PDFIncremental learning algorithm for dynamic evolution of domain specific vocabulary with its stability and plasticity analysis.
Sci Rep
January 2025
Department of Computer Science, Sri Guru Gobind Singh College of Commerce, University of Delhi, Delhi, India.
Domain-specific vocabulary, which is crucial in fields such as Information Retrieval and Natural Language Processing, requires continuous updates to remain effective. Incremental Learning, unlike conventional methods, updates existing knowledge without retraining from scratch. This paper presents an incremental learning algorithm for updating domain-specific vocabularies.
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