Background: Nuclear morphometry may provide useful diagnostic and prognostic information about basal cell carcinomas (BCCs) of the skin.
Material/methods: A morphometric analysis was performed on histological sections of 52 primary BCCs which recurred and of 52 cases of BCC which did not recur. Eighteen different morphometric parameters were considered, e.g. nuclear area, perimeter, elongation, convexivity, and gray level of the nucleus. The demographics of these patients and the histological-morphological characteristics of their tumors were also considered. Statistical analysis was performed to evaluate the prognostic and predictive value of the morphometric variables for the recurrence of BCCs.
Results: Increased patient age, multiple localization of BCCs at the time of diagnosis, and a low degree of peripheral palisading at the histological sections of BCCs were associated with BCC recurrence and consequently worse disease-free survival (DFS). 'Darker' values of the maximum nuclear gray level as well as greater variance of nuclear gray level values also strongly related to BCC recurrence and worse DFS. The analysis of the morphometry according to the histological types of BCC revealed that nodular BCCs consist of larger cells with statistically significant increased perimeter, minimum exterior axis, nuclear area, surface and perimeter of convexivity, and equivalent circle diameter. Infiltrating, sclerosing, and superficial BCCs, which tend to relapse, showed to consist of smaller cells with greater intercellular distance.
Conclusions: Nuclear morphometry evaluated with computer-assisted image analysis may contribute to a better knowledge and outcome prediction of BCC.
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Lancet Diabetes Endocrinol
January 2025
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK. Electronic address:
Background: Data on the effect of mineralocorticoid receptor antagonist therapy on HbA levels and new-onset diabetes are conflicting. We aimed to examine the effect of oral finerenone, compared with placebo, on incident diabetes in the Finerenone Trial to Investigate Efficacy and Safety Superior to Placebo in Patients with Heart Failure (FINEARTS-HF) trial.
Methods: In this randomised, double-blind, placebo-controlled trial, 6001 participants with heart failure with New York Heart Association functional class II-IV, left ventricular ejection fraction 40% or higher, evidence of structural heart disease, and elevated N-terminal pro-B-type natriuretic peptide levels were randomly assigned to finerenone or placebo, administered orally.
Vet Anim Sci
March 2025
Animal Science Research Department, Fars Agricultural and Natural Resources Research and Education Center, Agricultural Research, Education and Extension Organization (AREEO), Shiraz, Iran.
This study aims to measure the effects of different dietary concentrations of triticale hay (TH) on productive performance, carcass characteristics, microbial protein synthesis (MPS), ruminal and blood variables, and antioxidant power in 40 fattening male Gray Shirazi lambs (BW of 33.2 ± 1.1 kg) over 81 days in a completely randomized design (10 animals/diet).
View Article and Find Full Text PDFHeliyon
July 2024
Faculty of Humanities and Social Sciences, Macao Polytechnic University, Macao.
Background: The link between the digital economy and prosperity is well established. However, the mechanism underlying the relationship between the digital economy and common prosperity is yet to be investigated.
Study Rationale And Purpose: The main purpose of this study is to address this mechanism by examining the extent to which the digital economy has optimized regional investments in protecting the environment, particularly the resilience of environmental investment, thus influencing common prosperity.
Cureus
December 2024
Anna and Peter Brojde Lung Cancer Center, Sir Mortimer B. Davis Jewish General Hospital, McGill University, Montreal, CAN.
Background A minority of patients receiving stereotactic body radiation therapy (SBRT) for non-small cell lung cancer (NSCLC) are not good responders. Radiomic features can be used to generate predictive algorithms and biomarkers that can determine treatment outcomes and stratify patients to their therapeutic options. This study investigated and attempted to validate the radiomic and clinical features obtained from early-stage and oligometastatic NSCLC patients who underwent SBRT, to predict local response.
View Article and Find Full Text PDFJ Intellect Dev Disabil
June 2024
NOFASD, Perth, Australia.
Background: Australia has limited supports to help families where Fetal Alcohol Spectrum Disorder (FASD) impacts children and young people. National Organisation for Fetal Alcohol Spectrum Disorder Australia (NOFASD), in conjunction with the University of Otago, New Zealand, piloted and established a 7-week online program to assist caregivers to develop strategies and supports to help their families live well in a disabling society.
Method: The online program, Families Linking with Families (FLWF), was delivered to 88 caregivers.
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