The oxindolylidene acetic acids having long N-alkyl chains exhibited strong inhibitory activity toward dual specificity phosphatase Cdc25A.
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http://dx.doi.org/10.1016/j.bmcl.2008.04.027 | DOI Listing |
Org Lett
March 2018
Division of Organic Chemistry , CSIR-National Chemical Laboratory , Pune 411008 , India.
A novel process for the preparation of various ( E)-oxindolylidene acetates using arynes and carbamoylpropiolates has been developed. The utility of this protocol is also further extended to the one-pot synthesis of complex spirooxindolopyrrolidones. This method provides a milder and transition-metal-free access to both of the target scaffolds in moderate to good yields.
View Article and Find Full Text PDFOrg Biomol Chem
January 2016
National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 11221, Taiwan.
Tandem reactions use consecutive reaction steps to efficiently synthesize compounds of high molecular complexity. This paper presents a tandem Pd-catalyzed Heck and alkoxycarbonylation reaction for the stereoselective synthesis of (E)-oxindolylidene acetates. The mechanism underlying the Pd-catalyzed tandem reaction involves the syn-carbopalladation of ynamides followed by alkoxycarbonylation with CO and alcohol.
View Article and Find Full Text PDFBioorg Med Chem Lett
June 2008
Faculty of Pharmaceutical Sciences, Doshisha Women's College of Liberal Arts, Kodo, Kyotanabe, Kyoto 610-0395, Japan.
The oxindolylidene acetic acids having long N-alkyl chains exhibited strong inhibitory activity toward dual specificity phosphatase Cdc25A.
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