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A New Fluorescence Probe for the Quantification of Acetylcysteine and Carbocisteine in Bulk and Spiked Urine: Greenness Appraisal by Exploiting Different GAC-Metric Strategies.
Luminescence
January 2025
Department of Chemistry, Faculty of Science, Damanhour University, Damanhour, Egypt.
Herein, a novel spectrofluorometric sensor is proposed for the sensitive analysis of two nonfluorescent mucolytic drugs, namely, acetylcysteine (ACT) and carbocisteine (CST), utilizing the newly synthesized 2-[(2-hydroxyethyl)-(2,8,10-trimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-4-yl)-amino]-ethanol as a fluorescence probe (Flu. Probe). This fluorophore exhibits fluorescence emission at 445 nm upon excitation at 275 nm.
View Article and Find Full Text PDFAchieving Narrowband and Stable Pure Blue Organic Light-Emitting Diodes by Employing Molecular Vibration Limited Strategies in the Extended π-Conjugated Indolocarbazole Skeleton.
Adv Sci (Weinh)
January 2025
Jihua Hengye Electronic Materials Co. Ltd., Foshan, Guangdong, 528200, P. R. China.
B- and N-heterocyclic fluorophores have reveal promising efficiency in blue organic light-emitting diodes (OLEDs) with small full-width-at-half-maximum (FWHM). However, their structural determinants for spectral broadening and operating stability are still needed to be investigated in further. Herein, a novel multi-N-heterocycles Diindolo[3,2,1jk:3',2',1'jk]dicarbazole[1,2-b:4,5-b] (DIDCz) is proposed to manipulate the emission color toward pure blue region by extending π-conjugation of the N-π-N bridge.
View Article and Find Full Text PDFAmidine-functionalized aggregation-induced emission luminogen and a 3D-printed digital sensor platform for ultrafast and visual detection of heparin.
Anal Chim Acta
February 2025
College of Chemistry, Henan Joint International Research Laboratory of Green Construction of Functional Molecules and Their Bioanalytical Applications, Food Laboratory of Zhongyuan, Zhengzhou University, Zhengzhou, 450001, China.
Background: Heparin is a widely used anticoagulant in clinic. However, improper dosing can increase the risk of thromboembolic events, potentially leading to life-threatening complications. Clinic monitoring of heparin is very important for its use safety.
View Article and Find Full Text PDFQuantitative fluorescent nanoparticle tracking analysis and nano-flow cytometry enable advanced characterization of single extracellular vesicles.
J Extracell Biol
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RoseBio Milano Italy.
Current state-of-the-art tools for analysing extracellular vesicles (EVs) offer either highly sensitive but unidimensional bulk measurements of EV components, or high-resolution multiparametric single-particle analyses which lack standardization and appropriate reference materials. This limits the accuracy of the assessment of marker abundance and overall marker distribution amongst individual EVs, and finally, the understanding of true EV heterogeneity. In this study, we aimed to define the standardized operating procedures and reference material for fluorescent characterization of EVs with two commonly used EV analytical platforms-nanoparticle tracking analysis (NTA) and nano-flow cytometry (nFCM).
View Article and Find Full Text PDFFlow-Dependent Modulation of Endothelial Ca Dynamics by Small Conductance Ca-Activated K Channels in Mouse Carotid Arteries.
Biomedicines
December 2024
Department of Physiology and Cell Biology, University of South Alabama College of Medicine, Mobile, AL 36688, USA.
Background: Small conductance Ca activated K channels (K2.3) are important regulators of vascular function. They provide Ca-dependent hyperpolarization of the endothelial membrane potential, promoting agonist-induced vasodilation.
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