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A novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis.
Acta Neuropathol Commun
January 2025
Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center Unit 1374, 1155 Pressler St, Houston, TX, 77030-3721, USA.
Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs, lymph nodes, and bone is commonly reported, distant spread to the central nervous system almost never occurs. Here we present an unusual case of a patient with renal medullary carcinoma with metastasis to the brain following treatment which included tazemetostat, an EZH2 inhibitor.
View Article and Find Full Text PDFHuman neural rosettes secrete bioactive extracellular vesicles enriched in neuronal and glial cellular components.
Sci Rep
January 2025
Centro de Investigación en Medicina Traslacional "Severo R. Amuchástegui" (CIMETSA), Instituto Universitario de Ciencias Biomédicas de Córdoba (IUCBC), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Av. Naciones Unidas 420, Barrio Parque Vélez Sarsfield, X5016KEJ, Córdoba, Argentina.
Extracellular vesicles (EVs) play a critical role in the development of neural cells in the central nervous system (CNS). Human neural rosettes (hNRs) are radial cell structures that assemble from induced pluripotent stem cells (hiPSCs) and recapitulate some stages of neural tube morphogenesis. Here we show that hiPSCs and hNRs secrete EVs (hiPSC-EVs and hNR-EVs) with distinctive protein cargoes.
View Article and Find Full Text PDFMetabolic acidosis and sudden infant death syndrome: overlooked data provides insight into SIDS pathogenesis.
World J Pediatr
December 2024
Adelaide Medical School, Faculty of Health and Medical Sciences, The University of Adelaide, North Terrace, Adelaide, South Australia, 5006, Australia.
Article Synopsis
- Recent research into Sudden Infant Death Syndrome (SIDS) suggests that metabolic acidosis and sepsis are significant factors, challenging the traditional brain-centered theories that have dominated the field for decades.
- Analysis of various studies indicates that infections might play a crucial role, as many SIDS risk factors are tied to infection, which could lead to organ failure and respiratory issues in infants.
- The paper advocates for including specific metabolic tests (like pH and bicarbonate levels) in autopsies of unexpected child deaths to better understand the underlying causes of SIDS.
From Relief to Rash: Unexpected Hypersensitivity to Bupropion.
Prim Care Companion CNS Disord
December 2024
New Jersey Institute for Successful Aging, Rowan-Virtua School of Osteopathic Medicine, Stratford, New Jersey.
Transient biopsy-proven progressive multifocal leukoencephalopathy-immune reconstitution inflammatory syndrome (PML-IRIS) in an elderly woman without known immunodeficiency: a case report.
BMC Neurol
November 2024
Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
Background: Progressive multifocal leukoencephalopathy (PML) is a severe opportunistic brain disease caused by lytic JC polyomavirus (JCPyV) replication in oligodendrocytes. Although JCPyV infection is common in the general population, PML almost exclusively occurs in patients immunocompromised due to untreated HIV/AIDS, haematological malignancies, primary immunodeficiencies, solid organ transplantation, or immunomodulatory treatment of autoimmune diseases. There is no effective antiviral treatment, and recovery depends on immune reconstitution.
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