In situ preparation of glycoconjugate hollow microspheres mimics the extracellular matrix via interfacial polymerization.

A novel chitin-graft-polyleucine microsphere with hollow construction was prepared via ring-opening polymerization initiated with chitin based on interfacial protocol. The FT-IR and (1)H NMR analysis demonstrated the conjugation with regulated graft length. The study provided a facile one-step route to obtain microsphere with glycoconjugation structure. This hybrid polysaccharide-polypeptide microsphere may give promising application in drug delivery and tissue engineering.