Progress in secondary stroke prevention.

Ann Neurol

Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

Published: April 2008

Objectives: There are about 200,000 recurrent strokes each year in the United States. In addition, a large proportion of strokes are preceded by a transient ischemic attack. Therefore, secondary stroke prevention strategies are of great importance.

Methods: Select ongoing and recently completed studies were reviewed, with emphasis on those completed since the publication of secondary prevention guidelines. Ongoing studies that have the potential to modify existing recommendations are also mentioned.

Results: This review discusses recently completed and ongoing studies that have the potential to impact clinical practice. The topics discussed include hypertension, dyslipidemia, extracranial carotid and intracranial atherosclerotic disease, and antithrombotic therapy.

Interpretation: Recent studies have provided evidence that impact secondary stroke prevention.

Download full-text PDF

Source
http://dx.doi.org/10.1002/ana.21400DOI Listing

Publication Analysis

Top Keywords

secondary stroke
12
stroke prevention
12
ongoing studies
8
studies potential
8
progress secondary
4
prevention
4
prevention objectives
4
objectives 200000
4
200000 recurrent
4
recurrent strokes
4

Similar Publications

Prognostic impact of one-year permanent pacemaker implantation after mitral valve surgery with the Cox-maze procedure.

Eur J Cardiothorac Surg

January 2025

Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Republic of Korea.

Objectives: This study aimed to evaluate the prognostic impact of permanent pacemaker (PPM) implantation within the first year after mitral valve (MV) surgery combined with the Cox-maze procedure, focusing on long-term outcomes, including overall mortality, infective endocarditis (IE), and ischaemic stroke.

Methods: We conducted a retrospective cohort study using data from the National Health Insurance Service (NHIS) in South Korea, identifying 10,127 patients who underwent MV surgery with the Cox-maze procedure between 2005 and 2020. Patients were classified into the PPM and non-PPM groups based on PPM implantation within one year postoperatively.

View Article and Find Full Text PDF

Hyponatremia is associated with malignant brain edema after mechanical thrombectomy in acute ischemic stroke.

BMC Neurol

January 2025

Neurological Disorder Center, Department of Cerebrovascular Disease, Suining Central Hospital, Sichuan, 629000, China.

Background: Hyponatremia (< 135 mmol/L) is the most common electrolyte disturbance in patients with stroke. However, few studies have reported the relationship between hyponatremia at admission and outcomes in patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT). This study is aimed to explore the association between hyponatremia and clinical outcomes following MT.

View Article and Find Full Text PDF

This case report describes an otherwise healthy 43-year-old female who presented with severe pain, foot drop, and critical limb ischemia to her left foot caused by thrombosis of a peripheral artery secondary to antiphospholipid syndrome. Antiphospholipid syndrome is an autoimmune disease that frequently manifests as recurrent arterial and/or venous thrombotic events, ischemic strokes, and miscarriages. Antiphospholipid syndrome affecting primarily the arteries is less common as compared to venous thrombosis.

View Article and Find Full Text PDF

Importance: Nelonemdaz selectively antagonizes the 2B subunit of the N-methyl-d-aspartate glutamate receptor and scavenges free radical species.

Objective: To evaluate whether nelonemdaz enhances the clinical outcomes of patients with acute ischemic stroke undergoing emergent reperfusion therapy.

Design, Setting, And Participants: This multicenter double-blind placebo-controlled randomized phase 3 trial (December 25, 2021, to June 30, 2023, in South Korea) recruited patients with acute ischemic stroke who met the following criteria: National Institutes of Health Stroke Scale score greater than or equal to 8, Alberta Stroke Program Early Computed Tomography score greater than or equal to 4, and endovascular thrombectomy within 12 hours after stroke onset.

View Article and Find Full Text PDF

Background: Guideline-recommended strategies to interrupt chronic anticoagulation with warfarin or direct oral anticoagulants (DOAC) during the perioperative period of cardiac implantable electronic device (CIED) surgery differ worldwide. There is uncertainty concerning the benefits and harms of interrupted and uninterrupted anticoagulation in patients undergoing CIED surgery.

Objectives: To assess the benefits and harms of interrupted anticoagulation (IAC) with either warfarin or DOAC in the perioperative period of CIED surgery versus uninterrupted anticoagulation (UAC), with or without heparin bridging, during an equivalent time frame, for CIED surgery.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!