A common side effect of radiotherapy used in the treatment of oral cancer is the occurrence of structural and physiological alterations of the salivary glands due to exposure to ionizing radiation, as demonstrated by conditions such as decreased salivary flow. The present study evaluated ultrastructural alterations in the parotid glands of rats receiving a fractionated dose (1,500-cGy) of radiation emitted by a Cesium-137 source and rats that were not subjected to ionizing radiation. After sacrifice, the parotid glands were removed and examined by transmission electron microscopy. Damage such as cytoplasmic vacuolization, dilatation of the endoplasmic reticulum and destruction of mitochondria, as well as damage to the cellular membrane of acinar cells, were observed. These findings lead to the conclusion that ionizing radiation promotes alterations in the glandular parenchyma, and that these alterations are directly related to the dose level of absorbed radiation. Certain phenomena that appear in the cytoplasm and nuclear material indicate that ionizing radiation causes acinar cell death (apoptosis).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1590/s0103-64402008000100013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antibacterial mechanism of vitamin K-mediated photodynamic inactivation against Pseudomonas fluorescens and its influences on blunt bream (Megalobrama amblycephala) quality.
Food Res Int
January 2025
College of Food Science and Technology, Huazhong Agricultural University, National R & D Branch Center for Conventional Freshwater Fish Processing, Wuhan, Hubei Province 430070, PR China. Electronic address:
Photodynamic inactivation (PDI) has emerged as a novel non-thermal process technology for inactivating microorganisms due to its low cost, safety, and efficiency. This study aimed to investigate the antimicrobial effect of VK-mediated PDI against Pseudomonas fluorescens (P. fluorescens) and to assess its impact on the quality of the blunt bream contaminated with P.
View Article and Find Full Text PDFPolydopamine-integrated cellulose/graphene oxide monoliths: A versatile platform for efficient continuous-flow iodine capture and photothermal-enhanced reduction of Cr(VI).
Carbohydr Polym
March 2025
Department of Polymer Engineering, Pukyong National University, 45 Yongso-ro, Nam-gu, Busan 48513, Republic of Korea. Electronic address:
The global challenge of wastewater contamination, especially from persistent pollutants like radioactive isotopes and heavy metals, demands innovative purification solutions. Radioactive iodine isotopes (I and I), stemming from nuclear activities, pose serious health risks due to their mobility, bioaccumulation, and ionizing radiation, particularly impacting thyroid health. Similarly, hexavalent chromium, Cr(VI), is highly toxic and persistent in water, linked to cancer and other severe health issues.
View Article and Find Full Text PDFRadiation-induced cardiac disease: Modern techniques to reduce cardiac toxicity.
Pract Radiat Oncol
January 2025
The Legacy Heritage Oncology Center & Dr Larry Norton Institute, Soroka University Medical Center, Ben Gurion University of the Negev, Faculty of Medicine, Be'er Sheva, Israel.
Purpose: Continuous advancements in cancer management have resulted in increased long-term survival rates amongst cancer survivors and in turn have exposed the full extent of radiotherapy-associated morbidities. Radiation-induced coronary heart disease (RICHD) is one of the leading causes of morbidity and mortality in cancer survivors, particularly in those having undergone mediastinal radiation. While mediastinal radiation has been shown to substantially reduce both recurrence and mortality rates in multiple thoracic malignancies, the risk for the development of RICHD is of significant concern.
View Article and Find Full Text PDFUncovering molecular mechanisms of soybean response to C heavy ion irradiation through integrated transcriptomic and metabolomic profiling.
Ecotoxicol Environ Saf
January 2025
Plant Production Department, Faculty of Agriculture Saba Basha, Alexandria University, Alexandria 21531, Egypt; Work Station of Science and Technique for Post-doctoral in Sugar Beet Institute Afliated to Heilongjiang University, 74 Xuefu Road, Harbin 150000, Heilongjiang, China.
Ion beam mutagenesis is an advanced technique capable of inducing substantial changes in plants, resulting in noticeable alterations in their growth. However, the precise molecular mechanisms underlying the effects of radiation on soybeans remain unclear. This study investigates the impact of ionizing radiation on soybean development through a comprehensive approach that integrates transcriptomics and metabolomics.
View Article and Find Full Text PDFImpact of gamma radiation on marginal adaptation of nanohybrid composite and composition of dental hard tissues - Scanning electron microscopy and X-ray diffraction analysis: An pilot study.
J Conserv Dent Endod
November 2024
Department of Conservative Dentistry and Endodontics, Guru Nanak Dev Dental College and Research Institute, Sangrur, Punjab, India.
Aims: This pilot study aimed to compare the marginal adaptation of composite resin at the tooth-restoration interface, before and after radiation.
Subjects And Methods: Fifteen extracted premolars were divided into 2 experimental groups (based on the timing of irradiation) and 1 control group of 5 teeth each. In Group I (control group), teeth were restored but not exposed to radiation at any stage, Group II: teeth were irradiated before cavity preparation and restoration, and Group III: after cavity preparation and restoration employing selective etch technique, teeth were exposed to radiation.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!