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Implementation of the STEPPS program for the treatment of self-harm behaviors in Catalonia's prisons: barriers and facilitators.
BMC Public Health
January 2025
Department of Basic and Clinical Psychology, and Psychobiology, Universitat Jaume I, Castellon, Spain.
Background: The Systems Training for Emotional Predictability and Problem Solving (STEPPS) is an evidence-based program that has been shown to be effective in reducing self-harm behaviors in Correctional Settings (CS). However, there is limited understanding of the contextual factors that impact the implementation of this intervention within such complex environments. A comprehensive understanding of the implementation process is crucial for the successful adoption of this program.
View Article and Find Full Text PDFExploring the influence of pregnancy on cognitive function in women: a systematic review.
BMC Pregnancy Childbirth
January 2025
Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon.
Background: Pregnancy has been increasingly recognized for its potential impact on cognitive function influenced significantly by hormonal fluctuations such as estrogen and progesterone. However, the findings from research in this area remain debated, often varying with individual factors and pregnancy trimesters.
Objective: This study aims to systematically review existing literature and empirical research to better understand the phenomenon known as "pregnancy brain" and its association with cognitive change.
Toward a biological definition of neuronal and glial synucleinopathies.
Nat Med
January 2025
Department of Neurology & Neurological Sciences, Stanford Movement Disorders Center, Stanford University, Stanford, CA, USA.
Cerebral accumulation of alpha-synuclein (αSyn) aggregates is the hallmark event in a group of neurodegenerative diseases-collectively called synucleinopathies-which include Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Currently, these are diagnosed by their clinical symptoms and definitively confirmed postmortem by the presence of αSyn deposits in the brain. Here, we summarize the drawbacks of the current clinical definition of synucleinopathies and outline the rationale for moving toward an earlier, biology-anchored definition of these disorders, with or without the presence of clinical symptoms.
View Article and Find Full Text PDFError-driven upregulation of memory representations.
Commun Psychol
January 2025
Institute of Psychology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
Learning an association does not always succeed on the first attempt. Previous studies associated increased error signals in posterior medial frontal cortex with improved memory formation. However, the neurophysiological mechanisms that facilitate post-error learning remain poorly understood.
View Article and Find Full Text PDFSynaptic vulnerability to amyloid-β and tau pathologies differentially disrupts emotional and memory neural circuits.
Mol Psychiatry
January 2025
Institut de Neurociències, Department de Bioquímica i Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain.
Alzheimer's disease (AD) is characterized by memory loss and neuropsychiatric symptoms associated with cerebral amyloid-β (Aβ) and tau pathologies, but whether and how these factors differentially disrupt neural circuits remains unclear. Here, we investigated the vulnerability of memory and emotional circuits to Aβ and tau pathologies in mice expressing mutant human amyloid precursor protein (APP), Tau or both APP/Tau in excitatory neurons. APP/Tau mice develop age- and sex-dependent Aβ and phosphorylated tau pathologies, the latter exacerbated at early stages, in vulnerable brain regions.
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