The aim of the present study is to investigate the antiulcerogenic effects of the essential oil (EO) of Croton cajucara Benth in rats fed with a normal protein (NP) and low-protein diet (MN). NP and MN rats were treated with the essential oil for 15 days after chronic ulceration was induced. The EO accelerated healing of acetic acid-induced gastric lesions in NP and MN rats (p<0.05). In a similar experiment on chronic ulceration, Epidermal Growth Factor (EGF) mRNA expression increased in NP rats but not in MN rats. In assays of acute antiulcerogenic activity, C. cajucara increased somatostatin plasma levels and decreased gastrin plasma levels in both animal groups. The EO significantly prevented ethanol-induced gastric ulcers in NP and MN rats (p<0.001). Histological examination showed initial regeneration, formation of inflammatory infiltrate and angiogenesis in the epithelium surface of acetic acid-induced ulcers in NP and MN rats. C. cajucara prevented gastric lesions in both animal groups when ethanol methodology was used. We concluded that the EO showed an antiulcerogenic activity mediated by increased somatostatin secretion and EGF mRNA expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.phymed.2008.02.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Red sacaca essential oil-loaded nanostructured lipid carriers optimized by factorial design: cytotoxicity and cellular reactive oxygen species levels.
Front Pharmacol
October 2023
Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina, Brazil.
Amazonian flora includes several species with the potential to develop pharmaceutical and biotechnological products. The essential oils from Amazonian species possess some biological properties, such as antioxidant, antibacterial, and cytotoxic activities. The essential oil of red sacaca (RSO), Benth.
View Article and Find Full Text PDFDiabetes-Related Mechanisms of Action Involved in the Therapeutic Effect of Species: A Systematic Review.
Plants (Basel)
May 2023
Laboratorio de Etnofarmacología, Facultad de Ciencias, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán, CDMX C.P. 04510, Mexico.
Over the years, ethnopharmacological and phytochemical investigations have been conducted to understand the potential effects of the genus on several diseases. It has been revealed that these terpenoid-rich species traditionally used to treat gastrointestinal diseases, heal wounds, and relieve pain have a wide range of therapeutic effects; however, those used to treat diabetes, as well as their action mechanisms, have not been reviewed so far. Therefore, the main objective of this review was to compile all species that have shown pharmacological effects against diabetes and describe their action mechanisms.
View Article and Find Full Text PDF: Patents and Nanotechnological Advances.
Recent Pat Nanotechnol
July 2024
Programa de Pós-Graduação em Biotecnologia-RENORBIO/UFRN, Universidade Federal do Rio Grande do Norte, Natal, Brasil.
Benth showed several pharmacological properties such as: antiinflammatory, antinociceptive hypoglycemic, lipid-lowering, antiulcer, antiestrogenic, antitumor, antigenotoxic, antimutagenic, and cardiovascular. The 19--clerodane diterpene (-DCTN or DCTN) is the major bioactive constituent extracted from the bark of this . Patents for Benth in the period 2015 to 2022 comprises 14 published documents.
View Article and Find Full Text PDFNew derivative of trans-dehydrocrotonin isolated from Croton cajucara shows reduced cytotoxic and genotoxic effects in hepatocellular carcinoma (HepG2) cell line.
Toxicon
December 2022
Laboratório de Citogenética, Centro de Estudos Avançados da Biodiversidade, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address:
The Croton cajucara (Euphorbiales, Euphorbiaceae) plant occurs widely in the Amazon region, where its leaves and stem bark are consumed by the population to treat several diseases. The secondary metabolite trans-dehydrocrotonin (DCTN) is mainly accountable for the biological activities of this plant. However, prolonged consumption is associated with hepatotoxic effects due to the furan ring present in the molecule.
View Article and Find Full Text PDFProspecting of essential oils in combination with florfenicol against motile Aeromonas isolated from tambaqui (Colossoma macropomum).
Arch Microbiol
June 2022
Programa de Pós-Graduação Em Ciência Animal E Recursos Pesqueiros-PPGCARP, Universidade Federal Do Amazonas (UFAM), Av. General Rodrigo Octavio Jordão Ramos, 1200, Coroado I, Manaus, AM, 69067-005, Brazil.
Natural products with antimicrobial activity and their association with synthetic antimicrobials are a sustainable option in fish farming. The objective of this study was to determine antimicrobial activity, antibiofilm potential and synergism of five essential oils (EOs) with florfenicol against motile Aeromonas isolated from Amazonian Colossoma macropomum. As their major constituent, the EOs of the species of Aloysia triphylla, Croton cajucara (red and white morphotype), Cymbopongo citratus and Lippia gracilis present β-pinene (22.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!