We describe a method to study diffusion of rhodamine 6G dye in single silica nanochannels using arrays of silica nanochannels. Dynamics of the molecules inside single nanochannel is found from the change of the dye concentration in solution with time. A 10(8) decrease in the dye diffusion coefficient relative to water was observed. In comparison to single fluorescent molecule studies, the presented method does not require fluorescence of the diffusing molecules.
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