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Myocardial ketone body oxidation contributes to empagliflozin-induced improvements in cardiac contractility in murine heart failure.
Eur J Heart Fail
March 2025
University Medical Center Groningen, Department of Cardiology, University of Groningen, Groningen, The Netherlands.
Aims: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood. We sought to determine whether SGLT2i-induced improvements in cardiac function are dependent on increased cardiac oxidation of ketone bodies.
Methods And Results: We employed a mouse model with a cardiac-specific knock-out of the enzyme D-β-hydroxybutyrate dehydrogenase-1 (BDH1), rendering mice incapable of oxidizing the principal ketone body β-hydroxybutyrate in cardiomyocytes.
The Use of Shape Memory Alloys in Cages for Cervical Spinal Surgery.
J Neurol Surg A Cent Eur Neurosurg
March 2025
Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.
Background: Degenerative changes in the cervical spine can include the gradual loss of functionality of the intervertebral disks, development of osteophytes and ligament hypertrophy. Removal of the intervertebral disk and replacement with a cage (anterior discectomy and fusion [ACDF]) is a standardized operative procedure in these patients. The implant should provide structural support, should restore the physiologic lordosis, and enable a solid fusion.
View Article and Find Full Text PDFAsthma is a chronic respiratory condition characterized by airway inflammation, remodeling, and hyperresponsiveness to triggers causing airway constriction. Bronchial smooth muscle plays a critical role by narrowing airways, leading to obstruction and breathing difficulties, often exacerbated by mast cell infiltration and histamine release. Whereas current treatments, including bronchodilators, corticosteroids, and biologics provide effective management for most patients, alternative therapies are needed for difficult-to-treat asthma.
View Article and Find Full Text PDFHyperglycemia in poorly controlled diabetes is widely recognized as detrimental to organ dysfunction. However, the acute effects of hyperglycemia on brain metabolism and function are not fully understood. The potential protective benefit of ketone bodies on mitochondrial function in the brain has also not been well characterized.
View Article and Find Full Text PDFPoint-of-care β-hydroxybutyrate and glucose as candidate screening methods for ketoacidosis-associated death in forensic autopsy investigations.
Forensic Sci Int
February 2025
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada; Office of the Chief Coroner - Ontario Forensic Pathology Services, Toronto, ON, Canada. Electronic address:
Objectives: Ketone bodies, like β-hydroxybutyrate (BHB), derived from fatty acid breakdown, can cause fatal ketoacidosis if levels are excessively high. Postmortem diagnosis of ketoacidosis is challenging due to non-specificity of rapid chromogenic tests and the time required for LC-MS/MS analysis. This study investigates the feasibility of using point-of-care (POC) BHB and glucose testing to diagnose ketoacidosis-related deaths and distinguish between diabetic and other types of ketoacidosis, post-mortem.
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