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Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones.
Microb Cell Fact
December 2024
State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Background: Ribosome engineering is a semi-empirical technique used to select antibiotic-resistant mutants that exhibit altered secondary metabolism. This method has been demonstrated to effectively select mutants with enhanced synthesis of natural products in many bacterial species, including actinomycetes. Myxobacteria are recognized as fascinating producers of natural active products.
View Article and Find Full Text PDFReaL-MGE is a tool for enhanced multiplex genome engineering and application to malonyl-CoA anabolism.
Nat Commun
November 2024
State Key Laboratory of Microbial Technology, Shandong University, Qingdao, Shandong, P. R. China.
The complexities encountered in microbial metabolic engineering continue to elude prediction and design. Unravelling these complexities requires strategies that go beyond conventional genetics. Using multiplex mutagenesis with double stranded (ds) DNA, we extend the multiplex repertoire previously pioneered using single strand (ss) oligonucleotides.
View Article and Find Full Text PDFIxabepilone-Induced Delirium.
Am J Ther
September 2024
Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Corrigendum to "Epothilone B inactivation of Sirtuin1 promotes mitochondrial reactive oxygen species to induce dysfunction and ferroptosis of Schwann cells" [European Journal of Pharmaeutical Sciences 181 (2023) 106350].
Eur J Pharm Sci
December 2024
Department of Biomedical Engineering, School of Biomedical Engineering, Fourth Military Medical University, Xi'an, Shaanxi 710032, China. Electronic address:
A novel HER2 targeting nanoagent self-assembled from affibody-epothilone B conjugate for cancer therapy.
J Nanobiotechnology
August 2024
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Epothilone B (Epo B), a promising antitumor compound effective against various types of cancer cells in vitro. However, its poor selectivity for tumor cells and inadequate therapeutic windows significantly limit its potential clinical application. Affibody is a class of non-immunoglobulin affinity proteins with precise targeting capability to overexpressed molecular receptors on cancer cells, has been intensively investigated due to its exceptional affinity properties.
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