Scar formation is a physiologic reaction to dermal injury. We describe a 11-year-old girl and her 15-year-old cousin, who both presented with stellate scarlike lesions primarily located on the hands. Histopathologic examination confirmed scar tissue formation. There was no history of initiating trauma or other possible triggering factors. To our knowledge, this is the first reported case of spontaneous stellate scars in two young, second-degree family members, the exact pathogenesis of which remains to be elucidated.
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http://dx.doi.org/10.1111/j.1525-1470.2008.00644.x | DOI Listing |
J Toxicol Pathol
January 2025
The Institute of Environmental Toxicology, 4321 Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan.
Cystic degeneration (CD) in the liver is a cyst-like lesion composed of one or more pseudocysts lacking lining cells, occurring spontaneously in rats older than 12 months, with a male predilection. In this study, 32 CDs were identified in 23 out of 104 non-treated, control male Sprague-Dawley rats from two combined chronic toxicity and carcinogenicity studies with agrochemicals. They were examined histologically, histochemically, and immunohistochemically to assess the pathogenesis and pathological significance of CD, focusing on pseudocapillarization in aged rat liver.
View Article and Find Full Text PDFJ Vitreoretin Dis
December 2024
Retina Department, Fundación Hospital de Nuestra Señora de La Luz, Mexico City, Mexico.
Cell Biol Toxicol
December 2024
Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 13850 E. Montview Blvd, Box C238/V20-3128, Aurora, CO, 80045, USA.
Toxicant exposure can lead to acute liver injury, characterized by hepatic reprogramming and wound healing. Hepatic stellate cells (HSC) play a key role in liver regeneration during wound healing by secreting fibrogenic factors and production of extracellular matrix (ECM). However, repetitive injury to the liver can lead to extensive scarring and liver fibrosis, indicating HSCs coordinate both regeneration and disease.
View Article and Find Full Text PDFCan J Neurol Sci
October 2024
Division of Neurosurgery, Sunnybrook Health Sciences Center, Toronto, ON, Canada.
Exp Ther Med
December 2024
Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Saitama 359-8513, Japan.
Ischemic fasciitis (IF) is a rare pseudosarcomatous lesion usually occurring in physically debilitated or immobilized, elderly patients. The current case presents a 76-year-old mobile man with IF on his back. The 33-mm subcutaneous lesion, focally involving the latissimus dorsi muscle, had been slowly increasing in size for 2 months and was clinically suggested to be a soft-tissue sarcoma.
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