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New Immunosuppressants in Pediatric Kidney Transplantation: What's in the Pipeline for Kids?
Pediatr Transplant
February 2025
Department of Medicine III, Medical University of Vienna, Vienna, Austria.
The 1- and 5-year patient and graft survival rates of pediatric kidney transplant recipients have improved considerably in recent years. Regardless of early success, kidney transplantation is challenged by suboptimal long-term allograft and patient survival. Many kidney transplants are lost due to immune (rejection) and nonimmune allograft injuries, and patient survival is limited from cardiovascular disease, infection, and malignancy.
View Article and Find Full Text PDFSarcoidosis: A Review of the Guidelines and What's To Come.
Mo Med
October 2024
Assistant Professor, Pulmonary and Critical Care Fellow, Department of Pulmonary and Critical Care Medicine, University Health Hospital, University of Missouri-Kansas City, Kansas City, Missouri.
Article Synopsis
- Sarcoidosis involves granulomatous inflammation affecting almost all organ systems, with unresolved questions about its cause and mechanisms.
- Due to this uncertainty, creating effective diagnosis and treatment algorithms has been challenging, resulting in a lack of strong evidence-based practices.
- The article aims to compile and present guidelines and recommendations for diagnosing and managing sarcoidosis, along with insights into a new investigational treatment.
Promising therapeutic targets for the treatment of urine storage dysfunction: what's the status?
Expert Opin Ther Targets
April 2024
Wake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA.
Introduction: Opinions differ on what drugs have both a rationale and a development potential for the treatment of bladder storage dysfunction.
Areas Covered: In the present review, the focus is given to small molecule blockers of TRP channels (TRPV1, TRPV4, TRPA1, and TRPM8), P2 × 3receptor antagonists, drugs against oxidative stress, antifibrosis agents, cyclic nucleotide - dependent pathways, and MaxiK±channel - gene therapy.
Expert Opinion: TRPV1 channel blockers produce hypothermia which seems to be a problem even with the most efficacious second-generation TRPV1 antagonists.
Enabling food system innovation: accelerators for change.
Glob Food Sec
March 2024
Department of Global Development, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York, USA.
It is widely accepted that current food systems are not on a trajectory for achieving the Sustainable Development Goals by the end of the decade. Technological innovation will have a considerable role to play in different parts of the food system; many promising options exist or are in the pipeline, some of which may be highly disruptive to existing value chains. Scaling up the innovations required, at the same time as protecting those who may lose out in the short term, will require a strong enabling environment.
View Article and Find Full Text PDFESKAPE in China: epidemiology and characteristics of antibiotic resistance.
Emerg Microbes Infect
December 2024
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital of Medical School, College of medicine, Zhejiang University, Hangzhou, People's Republic of China.
The escalation of antibiotic resistance and the diminishing antimicrobial pipeline have emerged as significant threats to public health. The ESKAPE pathogens - Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp. - were initially identified as critical multidrug-resistant bacteria, demanding urgently effective therapies.
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