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| http://dx.doi.org/10.1016/s0828-282x(08)70189-2 | DOI Listing |
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Kinetic, thermodynamic, and ab initio insights of AsnGly isomerisation as a ticking time bomb for protein integrity.
Commun Chem
December 2024
Laboratory of Structural Chemistry and Biology, Institute of Chemistry, ELTE Eötvös Loránd University, Pázmány Péter sétány 1/A, 1117, Budapest, Hungary.
Under physiological conditions in peptides or proteins, the -AsnGly- motif autonomously rearranges within hours/days to β-Asp and α-Asp containing sequence, via succinimide intermedier. The formation of the succinimide is the rate-limiting step, with a strong pH and temperature dependence. We found that Arg(+) at the (n + 2) position (relative to Asn in the n position) favors isomerisation by forming a transition-state like structure, whereas Glu(-) disfavors isomerisation by adopting a β-turn like conformer.
View Article and Find Full Text PDFCircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.
Front Mol Biosci
December 2024
Department of Emergency Medicine and Laboratory of Emergency Medicine, West China Hospital, West China School of Medicine, Sichuan University Chengdu, Chengdu, China.
Introduction: The critical role of circular RNAs as non-coding RNAs in glioma has been extensively investigated. Therefore, we aimed to explore the role and potential molecular mechanisms of circRNA-mind bomb homolog 1 (circMIB1) in gliomas.
Methods: RNA sequencing was used to analyze the expression profiles of circRNAs in glioma tissues and normal brain tissues.
Case Report: A Ticking Time Bomb: Femoral Artery Aneurysm as a Complication of Behcet's Disease in Adolescents.
Int J Rheum Dis
December 2024
Department of Rheumatology and Immunology, Peking University International Hospital, Beijing, China.
Behcet's disease is a rare, chronic inflammatory disorder that can affect various organs, with large vessel involvement being particularly uncommon. This case report discusses a 17-year-old male with Behcet's disease who presented with a rapidly enlarging, painful mass in the right groin region, later diagnosed as a femoral artery aneurysm. The patient underwent successful surgical intervention and was subsequently managed with immunosuppressive therapy to prevent relapse.
View Article and Find Full Text PDFClinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients.
Endocr J
December 2024
Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan.
Adolescent and young adult (AYA, 15-39 years old) patients with papillary thyroid carcinoma (PTC) experience significant psychological distress and place great importance on obtaining information regarding the disease; however, their demands remain unmet. We aimed to investigate clinicopathological and molecular features of PTC in AYA patients and compare them to those of PTC in older patients (≥40 years). This retrospective study enrolled 1,677 patients diagnosed with PTC from January 2018 to December 2022, with 400 AYA patients and 1,277 older adults.
View Article and Find Full Text PDFDecades-old carbon reserves are widespread among tree species, constrained only by sapwood longevity.
New Phytol
December 2024
Center for Ecosystem Science and Society, Northern Arizona University, Flagstaff, AZ, 86011, USA.
Article Synopsis
- Carbon reserves in trees are influenced by past photosynthesis and can be dated using radiocarbon dating, allowing researchers to study their distribution and turnover.
- A new process model was created to analyze how different tree species manage their carbon reserves, revealing that both young and old reserves coexist within a single tree and are significantly mixed.
- Disturbances like drought, fire, and pests negatively affect reserve mixing and longevity, with older reserves showing notable age shifts after disturbances, suggesting that ecological variations across species play a critical role in reserve management.
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