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Construct validity and responsiveness of clinical upper limb measures and sensor-based arm use within the first year after stroke: a longitudinal cohort study.
J Neuroeng Rehabil
January 2025
Luzerner Kantonsspital, University, Teaching and Research Hospital, University of Lucerne, Lucerne, Switzerland.
Background: Construct validity and responsiveness of upper limb outcome measures are essential to interpret motor recovery poststroke. Evaluating the associations between clinical upper limb measures and sensor-based arm use (AU) fosters a coherent understanding of motor recovery. Defining sensor-based AU metrics for intentional upper limb movements could be crucial in mitigating bias from walking-related activities.
View Article and Find Full Text PDFEvaluation of the Digital Ventilated Cage® system for circadian phenotyping.
Sci Rep
January 2025
Sir Jules Thorn Sleep and Circadian Neuroscience Institute, Kavli Institute for Nanoscience Discovery, Nuffield Department of Clinical Neurosciences, University of Oxford, Dorothy Crowfoot Hodgkin Building, South Parks Road, Oxford, OX1 3QU, UK.
The study of circadian rhythms has been critically dependent upon analysing mouse home cage activity, typically employing wheel running activity under different lighting conditions. Here we assess a novel method, the Digital Ventilated Cage (DVC, Tecniplast SpA, Italy), for circadian phenotyping. Based upon capacitive sensors mounted under black individually ventilated cages with inbuilt LED lighting, each cage becomes an independent light-controlled chamber.
View Article and Find Full Text PDFLocalized K63 ubiquitin signaling is regulated by VCP/p97 during oxidative stress.
Mol Cell Proteomics
January 2025
Department of Biology, Duke University, Durham, NC, 27708, USA. Electronic address:
Under stress conditions, cells reprogram their molecular machineries to mitigate damage and promote survival. Ubiquitin signaling is globally increased during oxidative stress, controlling protein fate and supporting stress defenses at several subcellular compartments. However, the rules driving subcellular ubiquitin localization to promote concerted response mechanisms remain understudied.
View Article and Find Full Text PDFRevitalising strong cultural connections and resilience: Co-designing a pilot Elder-led mentorship program for Indigenous mothers in a remote northern community in Alberta, Canada.
Glob Public Health
December 2025
Indigenous Wellness Core, Alberta Health Services, Edmonton, Alberta, Canada.
Connecting with traditional knowledge and culture promotes the well-being of Indigenous parents and creates healthy environments for child development. Community Elders in a remote northern community in Alberta, Canada, collaborated with researchers to design a pilot Elders Mentoring Program. The programme aims to support young Indigenous mothers(-to-be), bringing back cultural traditions and teachings.
View Article and Find Full Text PDFData on effect of NPSB fertilizer rates on growth and yield of carrot ( L.) varieties in Gondar district, Northwestern Ethiopia.
Data Brief
February 2025
Department of Horticulture, College of Agriculture and Environmental Sciences, Debre Markos University. Po Box: 269, Ethiopia.
Carrot ( L.) is one of the most important root crops grown worldwide and in Ethiopia. However, its production and productivity are low due to a lack of improved varieties and unbalanced fertilizer rates, among other factors.
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