Since its introduction, the TIMI frame count method has contributed to the understanding of the pathophysiology of coronary artery disease. In this article, the evolution of the TFC method and its applicability in the assessment of various therapeutic modalities are described.
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TIMI frame count as a predictor of major adverse cardiovascular events during the first month after primary PCI.
Caspian J Intern Med
September 2024
Department of Cardiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
Article Synopsis
- This study examined the relationship between corrected Thrombolysis in Myocardial Infarction (TIMI) frame count (CTFC) and major adverse cardiovascular events (MACE) within a month after primary percutaneous coronary intervention (PPCI).
- The research included 80 patients at Ayatollah Rouhani Hospital, focusing on demographic data, coronary blood flow (CTFC), and the success of the intervention as indicated by ST segment resolution.
- Results showed no significant link between CTFC and MACE rates, although more than 50% ST segment resolution correlated with fewer cardiovascular events; ultimately, CTFC was deemed unreliable for predicting MACE in this timeframe.
Endocan may predict the presence of coronary slow flow and coronary artery disease.
Rev Assoc Med Bras (1992)
September 2024
Namık Kemal University, Faculty of Medicine, Department of Cardiology - Tekirdağ, Turkey.
Article Synopsis
- The study investigates the relationship between endocan levels and coronary artery disease (CAD) and coronary slow flow (CSF) in a group of 169 subjects undergoing coronary angiography.
- Both CAD and CSF patients exhibited significantly higher endocan levels compared to a control group, with similar levels between the two conditions, suggesting endocan's role in these diseases.
- Endocan levels, particularly when exceeding 450 pg/mL, are key predictors for both CAD and CSF, highlighting its potential as an important biomarker in these cardiovascular conditions.
The predictors of coronary slow flow in patients undergoing coronary angiography.
Egypt Heart J
August 2024
Faculty of Medicine, Mataram University, FK UNRAM, Jl. Pendidikan, No. 37, Mataram, NTB, Indonesia.
Background: A new challenge in coronary artery disease treatment has emerged, where specific populations exhibit ischemic symptoms without any obstruction in the epicardial coronary artery. Instead, they exhibit slow coronary contrast flow, referred to as coronary slow flow (CSF). This study aims to identify several predictors of CSF.
View Article and Find Full Text PDFMultimodality assessment of the coronary microvasculature with TIMI frame count versus perfusion PET highlights coronary changes characteristic of coronary microvascular disease.
Front Cardiovasc Med
June 2024
Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.
Background: The diagnosis of coronary microvascular disease (CMVD) remains challenging. Perfusion PET-derived myocardial blood flow (MBF) reserve (MBFR) can quantify CMVD but is not widely available. Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) is an angiography-based method that has been proposed as a measure of CMVD.
View Article and Find Full Text PDFEfficacy and Safety of Alprostadil in Microcirculatory Disturbances During Emergency PCI: A Meta-Analysis of Randomized Controlled Trials.
Am J Cardiovasc Drugs
July 2024
Medical Care Center, Hainan Affiliated Hospital of Hainan Medical University, Hainan General Hospital, No. 19, Xiuhua Road, Xiuying District, Haikou, 570311, Hainan Province, People's Republic of China.
Objective: The clinical advantage of alprostadil [prostaglandin E1 (PGE1)] in the treatment of microcirculatory disturbances (defined as no-reflow or slow-flow) in acute percutaneous coronary intervention (PCI) is still disputed. The purpose of our study was to review the efficacy of PGE1 supplements in patients with acute myocardial infarction (AMI) who had urgent PCI.
Design: This study was a meta-analysis of randomized controlled trials.
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