AI Article Synopsis
- - LAG-3 is a protein found on regulatory T cells that interacts with MHC class II molecules on antigen-presenting cells (APCs), which plays a role in immune regulation.
- - The study shows that when LAG-3 engages with MHC class II during interactions with dendritic cells (DCs), it inhibits their activation and maturation, resulting in a reduced immune response.
- - The inhibition occurs through a specific signaling pathway involving ITAM, FcgammaRgamma, and SHP-1, suggesting that regulatory T cells may suppress immune responses by affecting DC function.
Article Abstract
Lymphocyte activation gene-3 (LAG-3) is a CD4-related transmembrane protein expressed by regulatory T cells that binds MHC II on APCs. It is shown in this study that during Treg:DC interactions, LAG-3 engagement with MHC class II inhibits DC activation. MHC II cross-linking by agonistic Abs induces an ITAM-mediated inhibitory signaling pathway, involving FcgammaRgamma and ERK-mediated recruitment of SHP-1 that suppresses dendritic cell maturation and immunostimulatory capacity. These data reveal a novel ITAM-mediated inhibitory signaling pathway in DCs triggered by MHC II engagement of LAG-3, providing a molecular mechanism in which regulatory T cells may suppress via modulating DC function.
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| http://dx.doi.org/10.4049/jimmunol.180.9.5916 | DOI Listing |
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