Background: Malignant tumours of the stomach are common, but the incidence of stomach cancer varies from country to country, probably a result of genetic, epigenetic and environmental factors. Stomach cancer often occurs in older people whose stomachs produce only small quantities of acid. Although infection with Helicobacter pylori has been proven beyond doubt in the aetiopathogenesis of various gastric disorders, not much is known about the genotypes of H pylori infection in early-onset gastric cancer.
Aim: To ascertain the genotypes of H pylori in gastric cancer.
Methods: Ninety-two patients were separated into three groups on the basis of their endoscopic findings: group 1, gastric cancer; group 2, gastric ulcer; group 3, non-ulcer dyspepsia. Gastric biopsy specimens were obtained for culture and DNA isolation; additional specimens were taken from subjects with gastric cancer for histopathological analysis. Amplification was performed using specific oligonucleotide primers to obtain genotypic data. Four samples from each group were randomly selected for sequence analysis.
Results: Genotypic analysis showed cagT+ve/hrgA+ve/cagA+ve/cagE+ve/vacAs1+ve to be highly prevalent in 79% of cases of H pylori infection. This genotype was found in 88% of subjects in group 1 and 78% in group 2. Intestinal-type adenocarcinoma was found in 35 subjects (83%), 32 (9%) of which harboured this genotype. Sequence analysis showed no significant strain-specific variations.
Conclusions: Certain genotypes of H pylori have higher predictive value for the development of intestinal-type carcinoma at an early age. Genotyping of H pylori may well be a useful tool for screening people at increased risk of developing malignancy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/pgmj.2007.065060 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Menadione reduces the expression of virulence- and colonization-associated genes in .
Microbiology (Reading)
March 2025
School of Science and Technology, Nottingham Trent University, Nottingham, UK.
Novel treatment options are needed for the gastric pathogen due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied due to interest in its anti-bacterial and anti-cancer properties. Here, we investigated the effects of menadione on growth, viability, antibiotic resistance, motility and gene expression using clinical isolates.
View Article and Find Full Text PDFEndoscopic submucosal dissection (ESD), the standard treatment for early gastric cancer, typically results in homogeneous flat scars. However, in some cases, polypoid nodule scars (PNS) may develop, complicating the cancer recurrence assessment. This case report describes a 60-year-old man with a history of infection who underwent two ESD procedures: first for early antral gastric cancer and then for gastric body adenoma.
View Article and Find Full Text PDFFusobacterium nucleatum confirmed in gastric biopsies of patients without Helicobacter pylori.
BMC Res Notes
March 2025
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective: Putative associations between certain bacteria and gastric cancer have been described previously; however, the mechanisms underlying such associations are not thoroughly understood. We aimed to confirm the presence of Fusobacterium nucleatum in the biopsy samples of patients with gastroduodenal diseases, including gastric cancer, with concomitant or without Helicobacter pylori infection.
Results: Three hundred patients with gastroduodenal disorders, including gastritis, duodenal ulcer, or gastric cancer, were included.
Chitosan/hydroxypropylmethylcellulose based-mucoadhesive gastroretentive microparticles containing curcumin intended for the prevention of gastric ulcers.
Int J Pharm
March 2025
Department of Drugs and Pharmaceutics, School of Pharmaceutical Sciences, São Paulo State University (UNESP), 14800-903 Araraquara, SP, Brazil. Electronic address:
Gastric ulcer (GU) is a disease characterized by ulcerative lesions on the surface of the stomach mucosa caused mainly by health-related conditions, non-steroidal anti-inflammatory drugs (NSAIDs) use, and Helicobacter pylori infections. The treatment for this disease requires that the drug remains in contact with the site of action, however, the residence time of conventional dosage forms in this organ is limited due to gastric emptying. Curcumin (CUR) is a compound obtained from the rhizomes of the Curcuma longa plant and has been used in traditional Indian medicine for many centuries.
View Article and Find Full Text PDFUnveiling the therapeutic effects of traditional Chinese patent medicines: A network meta-analysis on chronic atrophic gastritis.
Medicine (Baltimore)
March 2025
Hunan Provincial Key Laboratory of Traditional Chinese Medicine Diagnostics, Hunan University of Chinese Medicine, Changsha, Hunan Province, China.
Background: The study aimed to conduct a network meta-analysis of randomized controlled trials (RCTs) to examine the effectiveness and safety of traditional Chinese patent medicine (TCPM), either used alone or combined with conventional treatment (CT) of chemical drugs, for treating chronic atrophic gastritis (CAG).
Methods: We searched the literature from database creation to December 2023; our primary endpoint was clinical response rate. Secondary outcome measures were the inhibition rate of Helicobacter pylori and clinical symptom score, including pain and noisy scores for the stomach, score for belch and acid reflux, score for the bitter taste and the dry throat, and safety according to total adverse events.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!