Purpose: Teratology Information Services (TIS) provide information on exposures during pregnancy and breast-feeding. Maintaining ongoing funding is a challenge. The purpose was to gather descriptive information on current TIS operations.
Methods: All North American TIS (16 American, 2 Canadian) completed a detailed survey.
Results: Service goal ranked as most important was correction of risk misperceptions. Inquiries were primarily for medications (mean 43.5%, S.D. 14.1), lactation exposures, and workplace exposures. Median employees per TIS: three (range 1-12.5). Two TIS only counsel health care professionals (HCPs). Main callers to remaining TIS were pregnant women (mean 46.8%, S.D. 22.8), physicians, and nurses. Calls per week varied (median 20, range 4-600). Median annual budget: US dollars 69,000 (range dollars 3000-335,000). Seventeen TIS collect patient data for research.
Conclusions: This survey was the first to document TIS operations in North America and demonstrates a spectrum of clinical and research activities, and provides data for a future cost-benefit analysis of TIS.
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http://dx.doi.org/10.1016/j.reprotox.2008.02.005 | DOI Listing |
Biosens Bioelectron
December 2024
Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian, 116024, China.
Stable and low-cost field-effect transistor (FET)-based biosensors are vital for the on-site detection of toxic pollutants in environmental monitoring applications. In this study, a tunable aptamer-MXene sensing interface was constructed to develop renewable FET biosensors. This was achieved through the reversible disulfide bond (-S-S-) reaction between the SH-TiCT film and thiolated aptamer.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Materials, Imperial College London, London, SW7 2AZ, UK.
Topological Insulators (TIs) are promising platforms for Quantum Technology due to their topologically protected surface states (TSS). Plasmonic excitations in TIs are especially interesting both as a method of characterisation for TI heterostructures, and as potential routes to couple optical and spin signals in low-loss devices. Since the electrical properties of the TI surface are critical, tuning TI surfaces is a vital step in developing TI structures that can be applied in real world plasmonic devices.
View Article and Find Full Text PDFNanoscale
December 2024
Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.
The convergence of nanotechnology and tissue engineering has paved the way for innovative cancer treatments that leverage the unique light absorption properties of nanomaterials. Indeed, photothermal therapy (PTT) and photodynamic therapy (PDT) utilize nanomaterials to convert near-infrared light into therapeutic energy for cancer treatment. This study focuses on the application of poly(lactic--glycolic acid) (PLGA) scaffolds, enhanced by graphene oxide, TiCT MXene, and TiS transition metal dichalcogenides for PDT and PTT treatments evaluated within 3D-bioprinted breast cancers.
View Article and Find Full Text PDFTransl Cancer Res
November 2024
Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Disulfidptosis is an emerging form of regulated cell death distinguished by abnormal disulfide stress and the collapse of the actin network. This study was to construct a prognostic model based on disulfidptosis-related lncRNAs (DRLs) to enhance survival prediction and assess their viability as biomarkers for immunotherapy response in neuroblastoma (NB).
Methods: Transcriptomic and clinical data from NB patients were obtained from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) and Gene Expression Omnibus (GEO) databases.
Colorectal Dis
December 2024
The National Centre for Peritoneal Malignancy, Mater Misericordiae University Hospital, Dublin, Ireland.
Aim: Low-grade appendiceal mucinous neoplasm (LAMN) of the appendix is a rare tumour that can progress to pseudomyxoma peritonei (PMP). There is a lack of standardization of surveillance following resection of LAMN as the progression rate to PMP is unclear. The aim of this study was to evaluate the rate of progression following resection of LAMN to PMP in a structured surveillance programme.
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