Salkovskis [1985. Obsessional-compulsive problems: A cognitive-behavioural analysis. Behaviour Research and Therapy, 23, 571-583.] hypothesized that intrusive thoughts are more likely to occur if the thought is salient for the individual, triggers feelings of responsibility and if the individual attempts to suppress the thought. The relationship between these three factors (responsibility, salience, thought suppression) and frequency of intrusive thoughts as well as anxiety were examined in the present study. One hundred female college students were led to believe that a snake had escaped from the cage in which it was housed. Half of the participants were led to believe that they were responsible for the snake's escape and half were not (Responsibility/No Responsibility). Half of the participants in each Responsibility condition were instructed to suppress thoughts of snakes during a stream of consciousness exercise and half were not (Thought Suppression vs. No Thought Suppression). All participants then completed a second stream of consciousness without suppression instructions. Salience groups were determined by a median split on a measure of snake fearfulness. Participants for whom the snake was a salient stimulus and who believed that they were responsible for the snake's escape had the highest frequency of snake thoughts during the second stream of consciousness task and also experienced the highest levels of state anxiety. Findings are discussed with respect to Salkovskis' model.
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http://dx.doi.org/10.1016/j.jbtep.2008.02.002 | DOI Listing |
Alzheimers Dement
December 2024
Johns Hopkins University, Baltimore, MD, USA.
Background: Alzheimer's disease is a progressive form of dementia where cognitive capacities deteriorate due to neurodegeneration. Interestingly, Alzheimer's patients exhibit cognitive fluctuations during all stages of the disease. Though it is thought that contextual factors are critical for unlocking these hidden memories, understanding the neural basis of cognitive fluctuations has been hampered due to the lack of behavioral approaches to dissociate memories from contextual-performance.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Indiana University, Bloomington, IN, USA.
Background: The roles of Aβ in the pathogenesis of Alzheimer 's disease (AD) include disruption of synaptic communication/function and synaptic plasticity mechanisms thought to underlie learning and memory. Exactly how these abnormal processes arise is incompletely understood, but evidence suggests that dysregulation of intracellular Ca levels is involved in alterations of neuronal excitability, synaptic remodeling, and neurodegeneration in AD. Our lab has focused on the potential involvement of voltage-gated potassium channels (VGKCs) in these processes, particularly Kv1.
View Article and Find Full Text PDFPsychophysiology
January 2025
Fudan Institute on Ageing, Fudan University, Shanghai, China.
It is common to make risky decisions under time pressure. However, there are ongoing debates regarding the interpretation of the intrinsic mechanisms through which time pressure influences risky decision-making. The current study, combining a sequential risk-taking task, behavioral modeling, and time-resolved multivariate pattern analysis on electroencephalography signals, explored the intrinsic mechanisms underlying the influence of time pressure on risky decision-making.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Psychology, University of York, York YO10 5DD, United Kingdom.
Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. Here, we show that sleep deprivation disrupts prefrontal inhibition of memory retrieval, and that the overnight restoration of this inhibitory mechanism is associated with time spent in rapid eye movement (REM) sleep. The functional impairments arising from sleep deprivation are linked to a behavioral deficit in the ability to downregulate unwanted memories, and coincide with a deterioration of deliberate patterns of self-generated thought.
View Article and Find Full Text PDFCureus
November 2024
Hematology and Medical Oncology, Al-Zahraa Medical College, Basrah, IRQ.
Autoimmune hemolytic anemia (AIHA) is a multifactorial disease that causes immune-mediated red blood cell destruction, resulting in anemia and hemolysis symptoms. Despite a significant understanding of its pathogenesis, the precise causes of AIHA remain largely unclear and are thought to be multifactorial. In this paper, we presented a case of sickle cell anemia who developed severe AIHA that failed to maintain response to multiple treatment lines, including steroids, intravenous immunoglobulin, rituximab, and immune suppressive medications.
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