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IQUB mutation induces radial spoke 1 deficiency causing asthenozoospermia with normal sperm morphology in humans and mice.
Cell Commun Signal
January 2025
Chongqing Key Laboratory of Human Embryo Engineering and Precision Medicine, Center for Reproductive Medicine, Women and Children's Hospital of Chongqing Medical University, Chongqing, 400010, China.
Background: Asthenozoospermia (ASZ) accounts for about 20-40% of male infertility, and genetic factors, contributing to 30-40% of the causes of ASZ, still need further exploration. Radial spokes (RSs), a T-shaped macromolecular complex, connect the peripheral doublet microtubules (DMTs) to a central pair (CP), forming a CP-RS-DMT structure to regulate the beat frequency and amplitude of sperm flagella. To date, many components of RSs and their functions in human sperm flagella remain unclear.
View Article and Find Full Text PDFA Systematic Review of Telemedicine Solutions to Provide Psychological Interventions for Women Receiving Fertility Treatments.
Telemed J E Health
January 2025
Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
Infertility and assisted reproduction treatment (ART) are frequently accompanied by the experience of emotional disorders. Psychological interventions are available for infertile populations, but the barriers of current face-to-face models of care difficult their dissemination. This systematic review (PROSPERO: CRD4202340179) aims to summarize how technologies are used in telemedicine psychological programs to manage emotional disorders in women undergoing fertility treatments.
View Article and Find Full Text PDFEffect of Donor Sperm on Quality of Life in Patients with Severe Oligoasthenosperm After ICSI Failure.
J Multidiscip Healthc
January 2025
Intensive Care Unit, Zhongshan Hospital, Fudan University, Shanghai, 200032, People's Republic of China.
Objective: To explore the effects of donor sperm on reproductive quality of life, sleep quality and erectile function in patients with severe oligoasthenospermia after the failure of intracytoplasmic sperm injection (ICSI), and to provide targeted reference for intervention.
Methods: From January 2021 to December 2023, patients with severe oligoasthenospermia who received assisted pregnancy treatment in Obstetrics and Gynecology Hospital Affiliated to Tongji University were selected as the study objects. Among them, 82 cases using sperm donor assisted pregnancy after ICSI failure were set as the observation group, and 82 cases using propensity score 1:1 matching ICSI failure after ICSI assisted pregnancy were set as the control group.
Investigation of cardiac remodeling and cardiac function on fetuses conceived via artificial reproductive technologies: a review.
J Perinat Med
January 2025
1st Department of Obstetrics and Gynecology, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
The prevalence of artificial reproductive technologies (ART), such as intra-uterine insemination (IUI), fertilization (IVF), and intracytoplasmic sperm injection (ICSI), has surged in response to the global increase in infertility rates, now impacting 17.5 % of couples. With over nine million babies born through ART, the safety and efficacy of these methods are largely recognized; however, emerging concerns regarding their association with prenatal and long-term health risks, especially cardiovascular disease (CVD), necessitate a thorough examination.
View Article and Find Full Text PDFSperm Morphology of Post-wash Sample and Its Association with Clinical Pregnancy among the Couples Undergoing Intrauterine Insemination: A Cohort Study.
J Hum Reprod Sci
December 2024
Department of Biostatistics, JIPMER, Puducherry, India.
Background: Intrauterine insemination (IUI) is an effective and inexpensive method of managing patients with unexplained and male factor infertility. It is attempted before proceeding to more invasive assisted reproductive techniques such as fertilisation and intracytoplasmic sperm injection. Numerous semen parameters have been assessed to indicate successful outcomes with IUI.
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