AI Article Synopsis
- A study was conducted on 31 children with congenital alpha 1-antitrypsin deficiency to assess liver fibrosis using procollagen type III peptide levels.
- There was no correlation between liver fibrosis severity assessed by histology and serum levels of procollagen type III peptide.
- Higher levels of this peptide were found in cases of cholestasis and external inflammatory conditions, indicating that inflammation can influence these measurements.
Article Abstract
In 31 children with congenital alpha 1-antitrypsin deficiency the concentration of procollagen type III peptide was determined in a trial establishing liver fibrosis degree and monitoring of fibrosis progression. No correlation was found between the degree liver fibrosis determined by histological examination and the serum concentration of procollagen type III peptide. The concentration of procollagen type III peptide was higher with coexistent cholestasis and in case of inflammatory processes outside the liver (pneumonia). In progressing cirrhosis with inflammatory reaction the concentration was higher than in advanced cirrhosis and non-inflammatory liver fibrosis.
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