AI Article Synopsis
- The study evaluated liver blood flow in 79 children with hepatitis B, divided into two groups: one with chronic active hepatitis and cirrhosis, and the other with prehepatic block.
- Liver blood flow was measured using a radioisotope scintiscan, revealing that children with cirrhosis (Group 1B) had a significantly lower portal to total liver blood flow ratio (HPI) compared to those with better liver function (Group 1A).
- Findings indicated that both children with prehepatic block and those with HBV cirrhosis had similar low HPI levels, along with an increase in arterial blood flow as portal flow decreased.
Article Abstract
The aim of the study was to evaluate the liver blood flow at different stages of hepatitis B as compared with prehepatic block. The examination was performed on 79 children aged 1-17 years who were divided in two groups. Group 1 consisted of 20 children with HBV chronic active hepatitis B: 10 children with liver efficiency (Gr. 1A) and 10 with liver cirrhosis (intrahepatic block) Gr. 1B. Group 2 comprised 59 children with prehepatic block. The liver blood flow was assessed with the help of a radioisotope liver scintiscan by the first flow technique using 99mTc-DTPA. The ratio of portal to total liver blood flow (HPI) and time of portal blood flow (T1/2) were estimated. In children from group 1A the HPI mean was 57% (N over 75%) and T1/2 was 7-8 sec (N4-7 sec) depending on age. In Group 1B the HPI mean was 25% and T1/2 was 9-13 sec. In most of the children with prehepatic block HPI was low (mean 22%) and was similar to that in children with cirrhosis due to HBV. The arterial blood flow increased while HPI showed a distinct decrease.
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