[Determination of dimethyl sulphate residual in granisetron hydrochloride by headspace gas chromatography].

Objective: To develop a headspace gas chromatography method for determining dimethyl sulphate residual in granisetron hydrochloride.

Methods: An Angilent INNOWAX capillary column with nitrogen gas as carrier and FID as detector was applied in this study. Dimethyl sulphate was tested under a constant column temperature.

Result: Dimethyl sulphate had different retention time from other organic solvents such as alcohol,acetoacetate, isopropanol, dichlormethane and chloroform, which might exist in granisetron hydrochloride. The detection limit of dimethyl sulphate;s was 0.0016%.

Conclusion: The method can be used for the determination of dimethyl sulphate residual in granisetron hydrochloride.