Objective: To investigate the existence of alternatively spliced variants of constitutive androstane receptor (CAR) in liver of mouse.
Methods: The nucleotide from liver of mouse was purified and the CAR cDNA was amplified by PCR. The fragments of CAR cDNA were cloned to T vector and sequence analysis was performed.
Result: Various spliced variants of CAR in liver mouse were confirmed by DNA sequencing.
Conclusion: There are alternatively spliced variants in CAR, which are located in the ligand binding sequence of CAR.
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| http://dx.doi.org/10.3785/j.issn.1008-9292.2008.02.002 | DOI Listing |
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