Background: Haloperidol is effective for postoperative nausea and vomiting prophylaxis, but there are almost no data comparing it to 5-HT(3) antagonists.
Methods: Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia. Nausea, vomiting, need for rescue, sedation, extrapyramidal effects, QTc intervals, and time to postanesthesia care unit discharge were evaluated with a third-party blind design.
Results: There was no intergroup difference in any measure of efficacy or toxicity. Haloperidol and ondansetron subjects (78.2% and 76.8%) had complete response. Postoperatively, prolonged QTc occurred in 28.9% and 22.1% (N.S.).
Conclusions: In a mixed surgical population, the efficacy and toxicity of postoperative nausea and vomiting prophylaxis with haloperidol 1 mg was not significantly different from ondansetron 4 mg.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1213/ane.0b013e3181609022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: Disparities in postoperative nausea and vomiting (PONV) and its prophylaxis may exist based on race, ethnicity, and socioeconomic status (SES). Our objective was to evaluate whether patients from racial and ethnic minority groups and patients from lower SES backgrounds received less appropriate PONV prophylaxis and experienced higher rates of PONV and post-discharge nausea and vomiting (PDNV).
Methods: This retrospective cohort study included 23,333 adults who underwent major surgeries (total knee arthroplasty, cholecystectomy, hysterectomy, and prostatectomy) from 2017-2022 in a single, multi-state hospital system.
Developing Topics.
Alzheimers Dement
December 2024
Brain and Spine Surgeons of Orange County, Newport Beach, CA, USA.
Background: It has been more than 20 years for a new treatment for Alzheimer's Disease (AD) to emerge. This treatment has recently been in the form of a monoclonal antibody targeting the end-products of neuronal death. We are testing the safety of a novel approach using activated stem cells injected directly into the ventricles of the brain.
View Article and Find Full Text PDFFactors Associated with Postoperative Pain Trajectory, Nausea and Vomiting After Total Knee Arthroplasty: A Retrospective Study.
Clin J Pain
January 2025
Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.
Objectives: Postoperative pain, nausea and vomiting adversely affect postoperative rehabilitation after total knee arthroplasty (TKA). We aimed to identify factors associated with postoperative pain trajectory and postoperative nausea and vomiting (PONV) and evaluated the effects of different analgesic modalities.
Methods: We retrospectively reviewed patients undergoing unilateral primary TKA from 2017 to 2022.
Analgesic Safety and Efficacy of Peri-Operative Posterior Cervical Muscle Plane Blocks in Elective Posterior Cervical Spine Surgery: A Systematic Review with Meta-Analyses.
Clin J Pain
January 2025
Department of Neurosurgery, University of Nebraska Medical Center. Omaha, Nebraska.
Objective: Posterior cervical spine surgery can result in significant discomfort in the post-operative period. Post-operative pain management presents a challenge, particularly in the elderly population which is more sensitive to adverse effects from analgesia. We aimed to compare outcomes after peri-operative posterior cervical muscle plane blocks versus patients who received general anesthesia only.
View Article and Find Full Text PDFActinomycosis in a Gallbladder Specimen: A Case Report.
Cureus
January 2025
Minimal Access Surgery, King's College Hospital NHS Foundation Trust, London, GBR.
Actinomycosis is a chronic, granulomatous infection caused by species, a group of anaerobic, gram-positive bacteria commonly found in the human oral cavity, gastrointestinal, and female genital tracts. Although it predominantly affects the cervicofacial region, rare manifestations such as gallbladder actinomycosis can occur. This report presents a case of gallbladder actinomycosis in a 61-year-old man who presented with a two-week history of right upper quadrant pain, jaundice, nausea, and vomiting.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!