Using a modified microkeratome, nasally based central corneal flaps were created on six human blind eyes at a depth of 300 microns. The flaps were allowed to heal with a bandage soft contact lens, using neither sutures nor bioadhesives. The optical quality of the corneas was evaluated with biomicroscopic examination, computer-assisted topography, and optical pachometry during a 3-month follow-up period. The maintenance of transparency and lack of distortion of the corneal surface 3 months after surgery support the concept that the flap technique may be useful in laser in situ keratomileusis.
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http://dx.doi.org/10.1001/archopht.1991.01080120083031 | DOI Listing |
Alzheimers Dement
January 2025
Stem Cells and Regenerative Medicine Laboratory, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, PR China.
Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disease and the leading cause of dementia. Recent research highlights meningeal lymphatics as key regulators in neurological diseases, suggesting that enhancing their drainage function could be a potential therapeutic strategy for AD. Our proof-of-concept study demonstrated that cranial bone transport can improve meningeal lymphatic drainage function and promote ischemic stroke recovery.
View Article and Find Full Text PDFOtolaryngol Head Neck Surg
January 2025
Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.
Objective: This study aims to identify factors associated with increased decision regret (DR) 12 months following treatment among head and neck cancer (HNC) patients.
Study Design: A retrospective observational cohort study.
Setting: Patients with newly diagnosed HNC at an academic tertiary care center from 2018 to 2023.
Cancer Rep (Hoboken)
January 2025
Histopathology Department, Teaching Hospital Anuradhapura, Anuradhapura, Sri Lanka.
Background: Basocellular carcinoma (BCC) is the most prevalent skin malignancy, often localizing to the UV-exposed skin of the face. While most BCC is relatively indolent, aggressive subtypes, including infiltrative BCC, pose the treatment challenges of ensuring functional and aesthetic preservation with a high risk of recurrence.
Case: A 78-year-old female patient complained of recurrent left chin BCC of infiltrative subtype, which was first treated in 2013 by wide local excision and adjuvant radiotherapy.
J Craniofac Surg
January 2025
Department of Plastic and Reconstructive Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Shijingshan District, Beijing, China.
The expanded forehead flap based on the frontal branch of the superficial temporal artery (STA-Fbr) is a versatile technique for reconstructing cervicofacial defects. The aim of this study was to summarize STA-Fbr forehead flap harvesting patterns. Between July 2003 and July 2023, 66 patients (43 males) underwent face and neck defect reconstruction using STA-Fbr-based forehead flaps.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
St Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, UK.
Background: The post-operative evaluation of trabeculectomy blebs has traditionally relied on subjective clinical grading systems performed at the slit-lamp. This study explores the use of swept source anterior-segment optical coherence tomography (AS-OCT) to objectively measure bleb internal reflectivity and morphology, and to distinguish blebs with surgical success vs. failure.
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