Background: Mental stress is associated with sympathetic adrenergic stimulation and concomitant increases in blood pressure and heart rate. Heritable individual differences in cardiovascular functional response to mental stress may arise from genetic variations in adrenergic receptors, which might produce excessive hemodynamic response to mental stress or create other conditions favoring the development of myocardial ischemia.
Methods: We examined the relationship between hemodynamic response to mental stress and mental stress-induced myocardial ischemia (MSIMI) and 5 common functional polymorphisms of beta1-adrenergic receptors (ADRB1 [OMIM 109630, accession No. 153]) and beta2-adrenergic receptors (ADRB2 [OMIM 109690, accession No. 154]). Participants were 148 patients (45 female [30.4%]) with a documented history of coronary artery disease and a mean (SD) age of 64 (9) years. Patients were enrolled between December 9, 2004, and February 21, 2007. Mental stress was induced via a public-speaking task. Rest and stress myocardial perfusion imaging was performed. Blood samples were collected and genotyped for 5 common functional polymorphisms of ADRB1 (codons 49 and 389) and ADRB2 (codons 16 and 27 and nucleotide 523). The main outcome measures were hemodynamic and myocardial ischemic responses to mental stress. Mental stress-induced myocardial ischemia was defined as new or worsening perfusion defects during mental stress with a summed (stress to rest) difference score of at least 3.
Results: A statistically significant difference was noted in the prevalences of MSIMI between genotype groups for codon 49 of ADRB1. Mental stress-induced myocardial ischemia occurred 3 times more frequently among patients homozygous for the Ser49 allele (31 of 104 patients [29.8%]) compared with 4 of 39 patients (10.3%) among the Gly49 allele carriers (P=.02). The adjusted odds ratio for the effect of genotype (Ser/Ser vs Gly carriers) on MSIMI was 3.9 (95% confidence interval, 1.2-12.5) (P=.02).
Conclusions: Our findings indicate an association between a common genetic variation in ADRB1 and myocardial ischemic response to mental stress in patients with coronary artery disease. This polymorphic genetic marker may help identify patients at increased risk for mental stress-induced adverse outcomes.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1001/archinte.168.7.763 | DOI Listing |
Blood Press Monit
February 2025
Health Promotion Unit, Fujitsu Limited, Kawasaki, Kanagawa Prefecture, Japan.
Objective: Stress and working environments are risk factors for hypertension. A new occupational health policy called the Stress Check Program was started in Japan in 2015. Therefore, we clarified whether the presence or absence of high job stress (HJS) as determined using the Brief Job Stress Questionnaire (BJSQ) is related to the comorbidity of hypertension.
View Article and Find Full Text PDFJ Am Coll Health
January 2025
Department of Psychological and Brain Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA.
Objectives: Adverse childhood experiences (ACEs) have been linked to posttraumatic stress symptoms (PTSS), but the role of contextual factors remains underexplored. Therefore, this study examined the moderating effect of campus climate on associations between ACEs and PTSS and whether effects differ based on racial/ethnic identity.
Participants: University students taking Psychology courses at a large public university in the Northeastern United States ( = 419).
Autism
January 2025
The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong.
This study aimed to examine whether an acceptance and commitment therapy (ACT)-based parenting program, incorporating topics of emotional and stress management, parenting skills training, autism-related education, and self-care learning, could be successfully implemented, well-received, and beneficial for parents of children with autism. We randomly assigned 40 parents to either participate in the eight-session ACT-based parenting program or receive usual care only. The program was found to be feasible, with many parents willing to participate and complete the sessions.
View Article and Find Full Text PDFEur J Breast Health
January 2025
Department of Psychology, Faculty of Humanities and Social Science, Bursa Technical University, Bursa, Turkey.
A significant number of scientific data concerning breast cancer is generated in Turkey. The present research reviewed postgraduate theses examining the psychological evaluation of breast cancer patients conducted in Turkey. The objective of the review study was to ascertain the focal topics of the theses, identify commonly examined psychological variables, determine research gaps, compare the frequency of experimental and intervention studies with other kinds of research, and provide recommendations for literature.
View Article and Find Full Text PDFCurr J Neurol
April 2024
Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Stress has been known as a risk factor for the onset and modification of autoimmune disorders such as myasthenia gravis (MG). However, the patients can control their stress and improve their quality of life (QOL) using some factors such as psychological and social support. Psychological capital and social support play a key role in decreasing stress and improving QOL in the patients with MG.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!