AI Article Synopsis
- A new minipig model was developed to study diabetes-related issues like delayed gastric emptying and irregular glucose metabolism.
- Intravenous injection of streptozotocin induced a diabetic state in minipigs, showing significant hyperglycemia and delayed gastric emptying over 80 weeks without major health issues.
- Mitemcinal treatment improved gastric emptying and stabilized post-meal glucose levels, suggesting its potential as a treatment for diabetic gastroparesis.
Article Abstract
Aims: This study was conducted to evaluate the suitability of a new minipig model for investigating aspects of diabetes such as delayed gastric emptying and glucose metabolism abnormalities, and to test the effects of mitemcinal (GM-611), an orally active erythromycin-derived motilin receptor agonist, on gastric emptying and postprandial glucose in normal and diabetic minipigs.
Methods And Results: Intravenous injection of 300 mg/kg streptozotocin (STZ) to 5-week-old minipigs induced moderate hyperglycemia (about 200 mg/dl) for >80 weeks without insulin treatment. Decreased insulin production (P<.05), increased area under the glucose curve (P<.05), and slower glucose disappearance (P<.05) were demonstrated, and there was no severe inhibition of body weight gain, liver failure, or renal failure. Gastric emptying was significantly delayed in diabetic minipigs (P<.05) at 80 weeks, but not at 40 weeks, post-STZ. Oral administration of mitemcinal (5 mg/kg) at 80 weeks accelerated gastric emptying and induced a similar postprandial glucose profile in normal and diabetic minipigs with delayed gastric emptying.
Conclusions: The new diabetic minipig model showed suitability for investigating diabetes, gastric emptying, and plasma glucose excursions. Since delayed gastric emptying and irregular plasma glucose excursions are characteristic of diabetic gastroparesis, the accelerating and regulating effects of mitemcinal on this model add to the existing evidence that mitemcinal is likely to be useful for treating diabetic gastroparesis.
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| http://dx.doi.org/10.1016/j.jdiacomp.2007.03.005 | DOI Listing |
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