Aim: To test the reliability and validity of the Pervasive Developmental Disorders Assessment System (PDDAS), a Japanese semistructured interview system.
Methods: The PDDAS, consisting of 91 items including 12 major items corresponding to 12 items in criterion A of DSM-IV autistic disorder criteria, 36 items on autistic symptoms and three Asperger's disorder (AS) screening items for diagnosing pervasive developmental disorders (PDD) and their subtypes and 40 items for other information including early development and past/family histories, was administered to mothers of 77 PDD children and 64 non-PDD children.
Results: The PDDAS had satisfactory interrater reliability (ranges of kappa, r and raw agreement rate were 0.69-1.00 in 76 items, 1.00 in 11 items and 0.91-1.00 in four kappa un-calculable items, respectively). Thirty-three of the 36 items and all of the 12 major items scored significantly higher in the PDD than non-PDD groups to show satisfactory discriminant validity. PDDAS and consensus DSM-IV diagnoses agreed in the 77 children in PDD diagnosis and disagreed in only two children in subtype diagnoses of autistic disorder and PDD not otherwise specified.
Conclusions: The PDDAS, which takes 1.5 h to administer, seems to have clinical and research utility, although further investigation is necessary.
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http://dx.doi.org/10.1111/j.1440-1819.2008.01759.x | DOI Listing |
Environ Pollut
December 2024
Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China. Electronic address:
Hydrogen sulfide (HS) is a pervasive environmental and industrial pollutant that poses a substantial threat to human health. Even short-term exposure to HS can result in severe respiratory and neurological damage. However, the underlying mechanisms of its biotoxicity remain unclear.
View Article and Find Full Text PDFInt J Dev Neurosci
February 2025
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
The folate cycle has been implicated in the pathophysiology of autism due to its role in the glutathione oxidative stress pathway, amino acid and DNA methylation reactions, and neurotransmitter synthesis pathway. Previous research on folinic acid supplementation in autistic children has suggested potential benefits. The primary aim of this pilot study was to determine the safety, feasibility and efficacy of oral folinic acid in improving communication and behaviour in autistic children.
View Article and Find Full Text PDFPsychosom Med
January 2025
From the Department of Psychology (Nevarez-Brewster, Han, Todd, Keim, Doom, Davis), University of Denver, Denver, Colorado; and Department of Pediatrics (Davis), University of California, Irvine, California.
Cognition
December 2024
University of Massachusetts Amherst, Department of Philosophy, 150 Hicks Way, Amherst, MA 01003, United States of America. Electronic address:
Generic statements ('Tigers have stripes') are pervasive and developmentally early-emerging modes of generalization with a distinctive linguistic profile. Previous experimental work suggests that generics display a unique asymmetry between the prevalence levels required to accept them and the prevalence levels typically implied by their use. This asymmetry effect is thought to have serious social consequences: if speakers use socially problematic generics based on prevalence levels that are systematically lower than what is typically inferred by their recipients, then using generics will likely exacerbate social stereotypes and biases.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Neuroscience Research Institute, University of California, Santa Barbara, CA 93106.
The molecular basis of human brain evolution is a key piece in understanding the evolution of human-specific cognitive and behavioral traits. Comparative studies have suggested that human brain evolution was accompanied by accelerated changes of gene expression (referred to as "regulatory evolution"), especially those leading to an increase of gene products involved in energy production and metabolism. However, the signals of accelerated regulatory evolution were not always consistent across studies.
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