An intermolecular nickel-catalyzed addition reaction has been developed where N-arylphthalimides react with alkynes to afford substituted isoquinolones. A mechanistic rationale is proposed, implying nucleophilic attack of Ni(0) to an amide as the primary step of the catalytic cycle.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ja7114426 | DOI Listing |
Publication Analysis
Top Keywords
nickel-catalyzed decarbonylative
4
decarbonylative addition
4
addition phthalimides
4
phthalimides alkynes
4
alkynes intermolecular
4
intermolecular nickel-catalyzed
4
nickel-catalyzed addition
4
addition reaction
4
reaction developed
4
developed n-arylphthalimides
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!