The influence of Actovegin on proliferation activity and mitotic regimen of cells of permanent lines PK-15-IEKVM and BHK-21 clone 13/04 was investigated. Addition of Actovegin into growth media containing bovine serums of different components and concentrations stimulates cell proliferation. Conclusion has been made that Actovegin can be used in cell culture biotechnology.
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Actovegin improves skeletal muscle mitochondrial respiration and functional aerobic capacity in a type 1 diabetic male murine model.
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Correction to: Actovegin® reduces PMA‑induced inflammation on human cells.
Eur J Appl Physiol
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View Article and Find Full Text PDFActovegin® reduces PMA-induced inflammation on human cells.
Eur J Appl Physiol
July 2020
Department of Dermatology and Allergy, University Hospital, LMU Munich, Munich, Germany.
Purpose: The effect of Actovegin® was investigated on PMA- and LPS-induced human peripheral blood mononuclear cells (PBMCs).
Methods: PBMCs (1 × 10 cells/ml) from five blood donors (2 f, 3 m; 45-55 years) were grown in medium and exposed to Actovegin® in the presence or absence of PMA or LPS. Supernatants were collected to assess the concentration of cytokines (TNF-α, IL-1beta, IL-6 and IL-10).
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