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Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein. | LitMetric
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Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein.

Yan-Ming Zhou Jia-Mei Yang Bin Li Zheng-Feng Yin Feng Xu Bin Wang Peng Liu Zhi-Min Li

World J Gastroenterol

Department of Hepato-Biliary-Pancreato-Vascular Surgery, The First Xiamen Hospital, Fujian Medical University, Xiamen, China.

Published: April 2008

Aim: To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP).

Methods: One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared.

Results: The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower.

Conclusion: ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703855PMC
http://dx.doi.org/10.3748/wjg.14.2251DOI Listing

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