AI Article Synopsis
- - The study aimed to understand the role of Thrombospondin-1 (TSP-1) in liver fibrosis and its connection to the formation of new blood vessels (angiogenesis).
- - Cirrhosis was induced in male rats using a specific chemical, and liver tissues were analyzed for TSP-1 and angiogenesis using antibodies and microscopy.
- - Results indicated that TSP-1 levels increase with the severity of fibrosis and are linked to angiogenesis, suggesting it might play a key role in liver damage and could be targeted in treating chronic liver conditions.
Article Abstract
Aim: To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis.
Methods: Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy.
Results: Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05).
Conclusion: The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-beta 1 (TGF-beta 1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2703847 | PMC |
| http://dx.doi.org/10.3748/wjg.14.2213 | DOI Listing |
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