AI Article Synopsis
- Di-isodecyl phthalate (DIDP) is a plasticizer commonly used in products like PVC, wires, and toys, and is linked to the activation of certain receptors in the body.
- In a study, Fischer 344 rats were fed various doses of DIDP for two years, leading to noticeable health effects such as weight loss and altered organ weights at the highest doses, but no cancerous changes were observed in vital organs.
- The findings indicate that DIDP may not be carcinogenic due to its limited ability to promote certain liver activities when compared to other phthalates like DEHP.
Article Abstract
Di-isodecyl phthalate (DIDP), a peroxisome proliferator-activated receptor-alpha activator, is widely used as a plasticizer in the manufacture of polyvinyl chloride (PVC), and ultimately in typical vinyl applications, particularly wire, cable and toys, etc. To examine its carcinogenic potential, DIDP was fed to Fischer 344 rats in the diet at doses of 0, 400, 2000 and 8000 ppm for 2 years. Briefly, significant decreases in the overall survival and body weights, and increases in the relative weights of kidneys and liver were noted in both sexes of the highest dose groups. However, no treatment-related neoplastic lesions were observed in the internal organs, including the liver. Unlike di(2-ethylhexyl) phthalate (DEHP), DIDP failed to maintain the catalase-inducing potential between early and late expressions of catalase protein from western blotting, immunohistochemistry and enzyme activity measurements. These results suggest that the non-carcinogenicity of DIDP in F344 rats was due to its limited potential for peroxisomal proliferating activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.toxlet.2008.02.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Eutrophication impacts on seasonal endocrine disrupting compounds (PAE and AP) accumulation in estuarine microplankton.
Mar Pollut Bull
December 2024
Sustainable Environment Research Center, College of Hydrosphere Science, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Department of Marine Environmental Engineering, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan; Institute of Aquatic Science and Technology, National Kaohsiung University of Science and Technology, Kaohsiung City 81157, Taiwan. Electronic address:
Article Synopsis
- The study examines the presence and seasonal changes of endocrine-disrupting compounds (EDCs), specifically phthalate esters (PAE) and alkyl phenols (AP), in marine microplankton over different seasons (Summer 2022, Autumn 2022, Spring 2023) in a polluted area.
- Sample analysis showed a wide range of concentrations of various EDCs, primarily di-isononyl phthalate (DiNP), di-(2-ethylhexyl) phthalate (DEHP), and nonylphenols (NP), with significant variability depending on the season.
- The research suggests that rivers are key to EDC distribution in microplankton, and factors like eutrophication
Association between phthalates exposure and non-alcoholic fatty liver disease under different diagnostic criteria: a cross-sectional study based on NHANES 2017 to 2018.
Front Public Health
October 2024
Department of Laboratory Medicine, Shenzhen Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen Key Laboratory of Medical Laboratory and Molecular Diagnostics, Shenzhen, China.
Article Synopsis
- - The study investigates the link between non-alcoholic fatty liver disease (NAFLD) and urinary phthalate metabolites, considering the rise of phthalate substitutes and variations in diagnostic approaches.
- - Analyzing data from 641 participants in the NHANES 2017-2018 database, researchers used three methods to diagnose NAFLD and assessed the concentration of various phthalate metabolites in urine.
- - Significant correlations were found between NAFLD and certain phthalate metabolites through logistic regression analysis, emphasizing the need for precise diagnostics in understanding NAFLD's development.
Bioaccessibility of plastic-related compounds from polymeric particles in marine settings: Are microplastics the principal vector of phthalate ester congeners and bisphenol A towards marine vertebrates?
Sci Total Environ
December 2024
Aquatic One Health Research Center (ARCUS) & Department of Analytical Chemistry, Nutrition and Food Chemistry, Universidade de Santiago de Compostela, R. Constantino Candeira S/N, IIAA building, Santiago de Compostela 15782, Spain. Electronic address:
Article Synopsis
- * The study developed in-vitro testing methods to analyze how much of these harmful chemicals leach from common plastic types (like polyethylene and PVC) in conditions that mimic marine environments and digestive systems.
- * Results showed that more hydrophilic compounds (DMP, DEP, BPA) leach significantly in saline waters with high bioaccessibility rates, leading to recommendations for a new dual-compartment gastrointestinal test to assess how these chemicals affect fish intake from various contamination levels.
Quantification of additives in beached plastic debris from Aotearoa New Zealand.
Sci Total Environ
November 2024
School of Physical and Chemical Sciences, University of Canterbury, Christchurch 8041, New Zealand.
Plastics have become an essential part of modern society. Their properties can be easily manipulated by incorporating additives to impart desirable attributes, such as colour, flexibility, or stability. However, many additives are classified as hazardous substances.
View Article and Find Full Text PDFImpacts of seasonal activities and traffic conditions on the contamination and accumulation of gully pot sediments: Metal(loid)s and organic substances.
Sci Total Environ
October 2024
Department of Civil, Environmental and Natural Resources Engineering, Luleå University of Technology, SE-97187 Luleå, Sweden.
Gully pots (GPs) are an integral urban drainage component, transferring surface runoff into piped systems and reducing sediment and contaminant load on downstream sewers and receiving waters. Sediment build-up in GPs impairs their hydraulic performance, necessitating maintenance for hydraulic function recovery. The variations in sediment accumulation rates between GPs suggested by earlier studies challenge the effectiveness of adopting a generalised maintenance frequency.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!