Autism is a common disorder of childhood. Yet, it often remains unrecognized and undiagnosed until or after late preschool age because appropriate tools for routine developmental screening and screening specifically for autism have not been available. Paediatricians have an important role in early recognition and evaluation of autism spectrum disorders because they usually are the first point of contact for parents. It is important that paediatricians are able to recognize the signs and symptoms of autism spectrum disorders and have a strategy for assessing them systematically. But paediatricians have also a role in chronic management of these disorders. The objective of this paper is to show a general view of the autism spectrum disorders (ASD) state of knowledge nowadays as well to stress the need of early detection and treatment of these disorders in order to improve better evolution and prognosis.
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Sensors (Basel)
December 2024
REMIT (Research on Economics, Management and Information Technologies), IJP (Instituto Jurídico Portucalense), Universidade Portucalense, Rua Dr. António Bernardino de Almeida, 541-619, 4200-072 Porto, Portugal.
Some previous studies have focused on using physiological signals to detect stress in individuals with ASD through wearable devices, yet few have focused on how to design such solutions. Wearable technology may be a valuable tool to aid parents and caregivers in monitoring the emotional states of individuals with ASD who are at high risk of experiencing very stressful situations. However, effective wearable devices for individuals with ASD may need to differ from solutions for those without ASD.
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December 2024
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction and communication. While many studies suggest that individuals with ASD struggle with emotion processing, the association between emotion processing and autistic traits in non-clinical populations is still unclear. We examine whether neurotypical adults' facial emotion recognition and expression imitation are associated with autistic traits.
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December 2024
Department of Psychiatry, Penn Center for Mental Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Many children on the autism spectrum engage in challenging behaviors, like aggression, due to difficulties communicating and regulating their stress. Identifying effective intervention strategies is often subjective and time-consuming. Utilizing unobservable internal physiological data to predict strategy effectiveness may help simplify this process for teachers and parents.
View Article and Find Full Text PDFPharmaceuticals (Basel)
November 2024
Division of Physiology, Department of Pharmacology, Physiology, and Microbiology, Karl Landsteiner University of Health Sciences, 3500 Krems, Austria.
Background: αδ proteins regulate membrane trafficking and biophysical properties of voltage-gated calcium channels. Moreover, they modulate axonal wiring, synapse formation, and trans-synaptic signaling. Several rare missense variants in CACNA2D1 (coding for αδ-1) and CACNA2D3 (coding for αδ-3) genes were identified in patients with autism spectrum disorder (ASD).
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Faculty of Nursing, Tokai University School of Medicine, Isehara 259-1193, Japan.
Retrotransposon Gag-like 4 (), a gene acquired from a retrovirus, is a causative gene in autism spectrum disorder. Its knockout mice exhibit increased impulsivity, impaired short-term spatial memory, failure to adapt to novel environments, and delayed noradrenaline (NA) recovery in the frontal cortex. However, due to its very low expression in the brain, it remains unknown which brain cells express RTL4 and its dynamics in relation to NA.
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