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Co-exposure to polyethylene microplastics and house dust mites aggravates airway epithelial barrier dysfunction and airway inflammation via CXCL1 signaling pathway in a mouse model.
Int Immunopharmacol
December 2024
Department of Allergology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; Department of Allergy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
Background: Environmental pollutants have been found to contribute to the development and acute exacerbation of asthma. Microplastics (MPs) have received widespread attention as an emerging global pollutant. Airborne MPs can cause various adverse health effects.
View Article and Find Full Text PDF[Analysis of the sensitization characteristics and changes trend of common allergens in a hospital of pediatric in Beijing City from 2019 to 2023].
Zhonghua Yu Fang Yi Xue Za Zhi
December 2024
Department of Allergy, National Clinical Research Center for Respiratory Diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing100045, China.
Article Synopsis
- The study examined changes in specific IgE (sIgE) test results for common allergens in children hospitalized from 2019 to 2023 to assist in diagnosing allergic diseases.
- A total of 44,633 test results were analyzed, split between food and inhaled allergens, revealing significant yearly increases in positive rates for both categories.
- Age-related differences in sensitization patterns were observed, with egg white being the most common food allergen in infants, and peanut allergies becoming prevalent in older children and adolescents.
CycloZ Suppresses TLR4-Driven Inflammation to Reduce Asthma-Like Responses in HDM-Exposed Mouse Models.
Cells
December 2024
R&D Center, NovMetaPharma Co., Ltd., Pohang 37668, Republic of Korea.
Asthma is a chronic lung disease characterized by airway inflammation, hyperresponsiveness, and narrowing, with a risk of life-threatening attacks. Most current treatments primarily consist of inhalable steroids, which are not without adverse effects. Recently, there has been growing interest in alternative approaches to asthma management.
View Article and Find Full Text PDFA Multi-centre Analysis of Serum IgE Levels in Atopic Dermatitis.
Indian J Dermatol
October 2024
From the Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective: To assess the characteristics of total immunoglobulin E (IgE) and allergen-specific IgE (sIgE) to 20 common allergens in 154 patients with atopic dermatitis (AD). To assess the correlation of clinical food allergy with positive food allergens' sIgE results. We further discuss the significance of IgE as a potential biomarker for AD disease severity.
View Article and Find Full Text PDFParasympathetic Airway Hyperreactivity Is Enhanced in Acute but Not Chronic Eosinophilic Asthma Mouse Models.
Am J Respir Cell Mol Biol
December 2024
Oregon Health & Science University, Portland, Oregon, United States;
Airway hyperreactivity in asthma is mediated by airway nerves, including sensory nerves in airway epithelium and parasympathetic nerves innervating airway smooth muscle. Isolating the function of these two nerve populations in vivo, to distinguish how each is affected by inflammatory processes and contributes to hyperreactivity in asthma, has been challenging. In this study, we used optogenetic acti-vation of airway nerves in vivo to study parasympathetic contributions to airway hyperreactivity in two mouse models of asthma: 1) acute challenge with house dust mite antigen, and 2) chronic airway hy-pereosinophilia due to genetic IL-5 overexpression in airways.
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