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http://dx.doi.org/10.1016/j.jacc.2007.12.038 | DOI Listing |
Aim: The relative apical sparing pattern of left ventricular (LV) longitudinal strain (RELAPS]>1) has been described as a typical sign of cardiac amyloidosis (CA). The objective was to validate this pattern in concomitant CA and aortic stenosis (AS) and to identify new echocardiographic variables suggestive of CA in the presence of AS.
Methods And Results: 324 consecutive patients (age 81.
Int J Cardiovasc Imaging
November 2024
Department of Nuclear Medicine, Bern University Hospital, Inselspital, University of Bern, Freiburgstrasse 18, Bern, 3011, Switzerland.
Aim: To assess in a phantom and in a clinical study the influence of different reconstruction parameters on quantitative SPECT/CT values in the assessment of cardiac transthyretin amyloidosis (ATTR-CA).
Method: A hybrid SPECT/CT camera with a proprietary software for SPECT/CT-based quantification of myocardial uptake of Tc-DPD was used. Images were reconstructed with 6 different protocols, differing in iterations, subset and Gaussian filter.
Future Cardiol
October 2024
Cardiology Department, Hospital Senhora da Oliveira - Guimarães, Guimarães, 4835-044, Portugal.
To evaluate the prevalence of TTR amyloid cardiomyopathy (ATTR-CM) in severe aortic stenosis (SAS) patients, and to determine the independent predictors of major adverse events (MAE). 91 SAS patients >65 years with an interventricular septum thickness ≥12.5 mm were referred for aortic valve replacement (AVR).
View Article and Find Full Text PDFCurr Opin Cardiol
September 2024
Houston Methodist Debakey Heart & Vascular Center, Houston, Texas, USA.
Purpose Of Review: Cardiac amyloidosis is a condition marked by the misfolding of precursor proteins into insoluble amyloid fibrils, leading to restrictive cardiomyopathy and heart failure symptoms. This review discusses advancements in nuclear imaging techniques that enhance the diagnosis and guide the management of cardiac amyloidosis, addressing the critical need for early and accurate detection in clinical practice.
Recent Findings: Recent studies and guidelines emphasizes the pivotal role of nuclear imaging techniques in diagnosing cardiac amyloidosis.
Front Cardiovasc Med
January 2024
Department of Cardiology, Hacettepe University Medical Faculty Hospital, Ankara, Turkey.
Objectives: This study has been conducted to investigate the non-invasive diagnostic journey of patients with a transthyretin amyloid cardiomyopathy (aTTR-CM) in Turkey, identify the challenges and uncertainties encountered on the path to diagnosis from the perspectives of expert physicians, and develop recommendations that can be applied in such cases.
Methods: This study employed a three-round modified Delphi method and included 10 cardiologists and five nuclear medicine specialists. Two hematologists also shared their expert opinions on the survey results related to hematological tests during a final face-to-face discussion.
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