A cure to prevent scoliosis from developing does not seem to be available in the near future. Primarily this is because of a lack of understanding of the aetiology of this devastating disease or cosmetic deformity. While extensive research has been performed in this area over the past 100 years many experiments have been poorly designed because they have been developed on the premise that patients with AIS all have the same, single underlying cause despite much evidence to the contrary. Consequently, much of the data in the literature can be challenged and perhaps explains the lack of significant progress. Certainly, the results from this previous research suggest strongly that a new approach needs to be adopted or the same confusing results will continue to be collected and little progress will be made. There are certain areas of research that hold the greatest potential for success in finding a cure. These are identified in this paper and included in a theoretical research laboratory. It is suggested that this laboratory need not be theoretical if modern, cheap communication systems were readily adopted throughout the world and if people were willing to share ideas readily and contact each other regularly. In perhaps an unconventional way, the emphasis of this paper is on finding a cure to prevent scoliosis from developing and uses the area of research into the aetiology of scoliosis as the platform for discussion.
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Gigascience
January 2025
Leibniz Institute for the Analysis of Biodiversity Change, Museum Koenig Bonn, 53113 Bonn, Germany.
Background: In this study, we present an in-depth analysis of the Eurasian minnow (Phoxinus phoxinus) genome, highlighting its genetic diversity, structural variations, and evolutionary adaptations. We generated an annotated haplotype-phased, chromosome-level genome assembly (2n = 50) by integrating high-fidelity (HiFi) long reads and chromosome conformation capture data (Hi-C).
Results: We achieved a haploid size of 940 megabase pairs (Mbp) for haplome 1 and 929 Mbp for haplome 2 with high scaffold N50 values of 36.
Front Public Health
January 2025
Department of Psychiatry and Neurosciences, Psychiatric University Clinic of Charité at St. Hedwig Hospital, Berlin, Germany.
Introduction: Female sex workers are a vulnerable hard-to-reach group. Research in this field is scarce due to several issues, such as methodological difficulties or societal stigmatization. Most of the available literature focuses on sexually transmittable diseases.
View Article and Find Full Text PDFWorld J Gastroenterol
January 2025
Université de Bourgogne, Institut Agro-INRAe, Dijon 21000, France.
The recent study exploring the bidirectional associations between gallstone disease, non-alcoholic fatty liver disease, and kidney stone disease highlights a critical concern in chronic disease management. Given the rising global prevalence of these conditions, understanding their interconnections is essential. The study emphasizes the importance of shared risk factors, such as obesity, type 2 diabetes, dyslipidemia, and oxidative stress, and calls for multidisciplinary screening strategies.
View Article and Find Full Text PDFWorld J Gastroenterol
January 2025
Department of Therapy, North Caucasus State Academy, Cherkessk 369000, Russia.
() infection has a protective effect on gastroesophageal reflux disease (GERD). Both of these diseases have a very high incidence and prevalence. As a result, GERD often recurs after anti- therapy.
View Article and Find Full Text PDFDiabetol Int
January 2025
Department of Endocrinology, Metabolism and Nephrology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-Ku, Tokyo, 113-8603 Japan.
Type 2 diabetes (T2D) is a polygenic disease, and the development of animal models by selective breeding is crucial for understanding its etiology, pathophysiology, complications, and treatments. We recently developed a new T2D model, the Oikawa-Nagao (ON) mouse, by selectively breeding mice with inferior glucose tolerance [diabetes-prone (ON mouse DP®; ON-DP) strain] and superior glucose tolerance [diabetes-resistant (ON mouse DR®; ON-DR) strain] on a high-fat diet. ON-DP mice are predisposed to develop diabetes and obesity after being fed a high-fat diet, compared to ON-DR mice.
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