Background: The association between socioeconomic position in middle age and risk of subsequent, short-term weight gain is unknown. We therefore assessed this association in a prospective population based cohort study in Norfolk, UK.
Methods: We analysed data on 14,619 middle-aged men and women (aged between 40-75 at baseline) with repeated objective measures of weight and height at baseline (1993-1997) and follow up (1998-2000).
Results: During follow up 5,064 people gained more than 2.5 kg. Compared with the highest social class, individuals in the lowest social class had around a 30% greater risk of gaining more than 2.5 kg (OR 1.29; 95% CI 1.11-1.51; p for trend = 0.002). This association remained statistically significant following adjustment for sex, age, baseline BMI, smoking, and follow up time (OR 1.25; CI 1.07-1.46; p for trend <0.001). We also found no material difference between unadjusted models and those including all confounders and potential mediators.
Conclusion: Individuals of low socioeconomic position are at greatest risk of gaining weight during middle age, which is not explained by classical correlates of socioeconomic position and risk factors for obesity.
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http://dx.doi.org/10.1186/1471-2458-8-112 | DOI Listing |
Background: Metabolic syndrome (MetS) has been previously associated with an increased risk of developing dementia. Exploring links between MetS, neuroimaging and cognitive function measures can offer insights into whether MetS adversely affects brain health prior to dementia onset. We sought to examine the association of MetS with brain structure and cognition.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Temple University College of Public Health, Philadelphia, PA, USA.
Background: The number of individuals with age-related cognitive impairment is projected to increase at an unprecedented rate over the next few decades due to demographic shifts. Recent research endeavors have been increasingly aimed at understanding risk factors at the neighborhood level, notably socioeconomic status (SES). This review aims to provide insight into the current state of knowledge on the role of neighborhood disadvantage, defined by neighborhood SES, on late-life cognitive outcomes.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
UCL, London, England, United Kingdom; MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Background: Midlife blood pressure is a risk factor for cognitive impairment. Yet, the directional relationship between blood pressure and memory may vary across adulthood, be confounded by earlier life factors, and vary by sex. Using a population-based cohort of people born in the same week, we investigate the bidirectional associations between diastolic blood pressure (DBP) and memory, spanning over 25 years of adulthood.
View Article and Find Full Text PDFBackground: Socioeconomic disadvantage at different life-course stages has been associated with later life cognitive impairment. However, its association with changes in cognitive function needs to be further elucidated. We assessed the association between socioeconomic position (SEP) throughout the life-course and cognitive function change in middle-aged and older Hispanic/Latino adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Hospital Clínico Universidad de Chile, Santiago, Region Metropolitana, Chile.
Background: Cardiovascular risk factors (CVRF) are among the main modifiable risk factors for dementia in Latin America (LA). Therefore, improving cardiovascular health (CVH) is one of the main objectives of the LatAm-FINGERS trial, the largest non-pharmacological (lifestyle improvement) randomized trial in LA. But, to fully comprehend CVH it is necessary to explore its relation with the social determinants of health (SDH), that are closely associated with lifestyle.
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