Pathogenesis of hemostasis disorders in septic peritonitis and the possibility of their correction with acute phase protein (alpha1-acid glycoprotein; two doses of 150 mg/kg) were experimentally studied on outbred albino rats. Platelets count in the peripheral blood and their adhesion to endothelium did not change during peritonitis, while aggregation activity increased due to increased rate and shorter time of aggregation, which was associated with the development of hypercoagulation involving the intrinsic and common coagulation pathways and reduction of antithrombin activity. alpha1-Acid glycoprotein increased platelet count above the normal level, normalized aggregation rate, some blood clotting parameters, and antithrombin activity. Hence, alpha1-acid glycoprotein is a polyfunctional protein modulating all pathogenetic components in the development of blood clotting disorders during septic peritonitis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-007-0283-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
How strong the interaction really are? Application of nanoITC in the analysis of the interaction between newly synthesized substances with potential anticancer activity and model carrier proteins.
Naunyn Schmiedebergs Arch Pharmacol
February 2025
Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40-055, Katowice, Poland.
The aim of this work was to extend the existing knowledge of the interaction between newly synthetized substances with anticancer properties (5-methyl-12(H)-chino[3,4-b]-[1,4]-benzothiazine chloride (Salt1), 9-fluoro-5-alkyl-12(H)-quino[3,4-b][1,4]benzothiazine chloride (Salt2), and 9-amino-5-alkyl-12(H)-quino[3,4-b][1,4]benzothiazine chloride (Salt3) with model plasma carrier proteins. The thermodynamic profile of ligand-protein complexation and the contribution of bonds responsible for complex formation have been studied using calorimetry technique. The research has theoretical and experimental nature, but from a scientific point of view is novelty due to promising biological properties of Salt1, Salt2, and Salt3 and provide an important basis for further in vitro and in vivo studies.
View Article and Find Full Text PDFDeterminants of acute phase reactant scores in well-appearing neonates with maternal risk factors for neonatal infection.
Pediatr Neonatol
January 2025
Daido Hospital, 9 Hakusui, Minami, Nagoya, Aichi, 457-8511, Japan; Center for Human Development and Family Science, Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho, Nagoya, 467-8601, Japan. Electronic address:
Aim: Approximately 99% of neonatal deaths from sepsis occur in low-to middle-income countries, highlighting the need for efficient screening tools. The Acute Phase Reactant (APR) score comprises C-reactive protein, α1-acid glycoprotein, and haptoglobin, and can be assessed using a latex agglutination kit without modern equipment and expertise. This study assessed APR-score inter-rater reliability and identified non-infectious independent variables associated with positive APR scores in well-appearing term neonates with maternal risk factors for neonatal infection.
View Article and Find Full Text PDFAbnormal Vessels Potentially Accelerate Glioblastoma Proliferation by Inducing the Protumor Activation of Macrophages.
Cancer Sci
February 2025
Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
Glioblastoma (GBM) involves disruptions in the blood-brain barrier (BBB) and alterations in the immune microenvironment, including the activation of glioma-associated macrophages (GAMs). Vascular endothelial growth factor inhibitors, commonly used in recurrent GBM treatment, can influence these processes. This study investigates the relationship between BBB disruption and GAM activation, focusing on plasmalemma vesicle-associated protein (PLVAP), a marker of BBB disruption, and α1-acid glycoprotein (AGP), an inflammatory protein implicated in tumor progression.
View Article and Find Full Text PDFCharacterizing the plasma protein binding profiles of chemistry diversified antisense oligonucleotides in human and mouse plasma using an ultrafiltration method.
Front Pharmacol
January 2025
Eisai, Cambridge, MA, United States.
Introduction: Plasma protein binding plays a significant role in influencing the pharmacokinetic and pharmacodynamic properties of drugs. This study focuses on examining two pairs of sequence-matched ASOs: phosphorodiamidate morpholino oligomers (PMOs) and 2'-O-methoxyethyl/phosphorothioate (MOE/PS)-modified ASOs, to assess their plasma protein binding profiles.
Methods: The binding of both PMO and MOE/PS-modified ASOs was investigated using an ultrafiltration method combined with hybridization electrochemiluminescence, allowing for the measurement of the unbound fraction (u) in both mouse and human plasma.
α-Acid Glycoprotein with Highly Fucosylated Glycans as a Potential Diagnostic Marker for Early Detection of Hepatobiliary and Pancreatic Cancers.
Diagnostics (Basel)
December 2024
Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
: Previously, we reported elevated levels of fucosylated α-acid glycoprotein (fAGP) in plasma samples from patients with diverse types of cancers. Accordingly, fAGP was assumed to be a potential biomarker for the early detection of cancers. : The fAGP level was retrospectively measured in preoperative plasma samples from 213 patients with either hepatic, biliary tract, or pancreatic cancer and was analyzed together with levels of six existing tumor markers determined as reference standards.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!